DRD1

(redirected from Dopamine D1 receptor)

DRD1

A gene on chromosome 5q35.1 that encodes G protein-coupled dopamine receptor D1, which is the most abundant dopamine receptor in the CNS. D1 dopamine receptors stimulate adenylyl cyclase and activate cyclic AMP-dependent protein kinases; they regulate neuronal growth and development, mediate some behavioural responses, and modulate dopamine receptor D2-mediated events.
References in periodicals archive ?
ITI-007 also exhibits mesocortical and mesolimbic selectivity as evidenced by regionally selective increases in dopamine release and phosphorylation of glutamatergic NMDA NR2B receptors in response to dopamine D1 receptor activation.
Simultaneous with the financial closing, Psyadon and Schering Corporation executed an agreement under which Psyadon will acquire worldwide rights to Schering's selective dopamine D1 receptor antagonist, ecopipam.
Ecopipam is a selective dopamine D1 receptor antagonist that was discovered by the Schering-Plough Research Institute, a division of Schering Corporation.
The improvement was related to dose levels, and was consistent with that seen in conventional therapies for PD such as dopamine D1 receptor agonists.
In addition to G-protein coupled receptors like the dopamine D1 receptor, a major focus of the research at CeNeS is on ion channels.
However, they also found that if they blocked the dopamine D1 receptors with drugs, Ritalin was unable to enhance learning.