DRD1

(redirected from Dopamine D1 receptor)

DRD1

A gene on chromosome 5q35.1 that encodes G protein-coupled dopamine receptor D1, which is the most abundant dopamine receptor in the CNS. D1 dopamine receptors stimulate adenylyl cyclase and activate cyclic AMP-dependent protein kinases; they regulate neuronal growth and development, mediate some behavioural responses, and modulate dopamine receptor D2-mediated events.
References in periodicals archive ?
Dopamine D1 receptor mutant mice are defident in striatal expression of dynorphin and in dopamine-mediated behavioral responses.
Genetic analyses have indicated a central importance of renal sodium handling in the determination of salt sensitivity, and particularly in the function of the renal dopamine D1 receptor in the proximal tubule (8-11).
The function of the dopamine D1 receptor in the renal proximal tubule depends on the interaction with G-protein receptor kinase 4 (GRK4).
Disruption of dopamine D1 receptor gene expression attenuates alcohol-seeking behavior.
Behavioral and molecular effects of dopamine D1 receptor stimulation during naloxone-precipitated morphine withdrawal.
Dopamine-opioid interactions in the rat striatum: a modulatory role for dopamine D1 receptors in delta opioid receptor-mediated signal transduction.
Reversal of antipsychotic-induced working memory deficits by short-term dopamine D1 receptor stimulation.
Characterization of in vivo pharmacokinetic properties of the dopamine D1 receptor agonist DAR-0100A in nonhuman primates using PET with [11C] NNC112 and [11C] raclopride.
However, they also found that if they blocked the dopamine D1 receptors with drugs, Ritalin was unable to enhance learning.