DRD1

(redirected from Dopamine D1 receptor)

DRD1

A gene on chromosome 5q35.1 that encodes G protein-coupled dopamine receptor D1, which is the most abundant dopamine receptor in the CNS. D1 dopamine receptors stimulate adenylyl cyclase and activate cyclic AMP-dependent protein kinases; they regulate neuronal growth and development, mediate some behavioural responses, and modulate dopamine receptor D2-mediated events.
References in periodicals archive ?
Dopamine D1 receptor mutant mice are defident in striatal expression of dynorphin and in dopamine-mediated behavioral responses.
Genetic analyses have indicated a central importance of renal sodium handling in the determination of salt sensitivity, and particularly in the function of the renal dopamine D1 receptor in the proximal tubule (8-11).
The function of the dopamine D1 receptor in the renal proximal tubule depends on the interaction with G-protein receptor kinase 4 (GRK4).
Disruption of dopamine D1 receptor gene expression attenuates alcohol-seeking behavior.
Behavioral and molecular effects of dopamine D1 receptor stimulation during naloxone-precipitated morphine withdrawal.
Dopamine-opioid interactions in the rat striatum: a modulatory role for dopamine D1 receptors in delta opioid receptor-mediated signal transduction.
Simultaneous with the financial closing, Psyadon and Schering Corporation executed an agreement under which Psyadon will acquire worldwide rights to Schering's selective dopamine D1 receptor antagonist, ecopipam.
Ecopipam is a selective dopamine D1 receptor antagonist that was discovered by the Schering-Plough Research Institute, a division of Schering Corporation.
Reversal of antipsychotic-induced working memory deficits by short-term dopamine D1 receptor stimulation.
Characterization of in vivo pharmacokinetic properties of the dopamine D1 receptor agonist DAR-0100A in nonhuman primates using PET with [11C] NNC112 and [11C] raclopride.
The improvement was related to dose levels, and was consistent with that seen in conventional therapies for PD such as dopamine D1 receptor agonists.
However, they also found that if they blocked the dopamine D1 receptors with drugs, Ritalin was unable to enhance learning.