Donovan bodies

Don·o·van bod·ies

(don'ŏ-văn),
clusters of blue or black staining, bipolar chromatin condensations in large mononuclear cells in granulation tissue infected with Calymmatobacterium granulomatis.

Donovan bodies

[don′əvan]
Etymology: Charles Donovan, Irish physician, 1863-1951
encapsulated gram-negative rods of the species Calymmatobacterium granulomatis, present in the cytoplasm of mononuclear phagocytes obtained from the lesions of granuloma inguinale. They may be seen under the microscope in a Wright-stained smear of infected tissue. See also granuloma inguinale.

Don·o·van bod·ies

(don'ŏ-văn bod'ēz)
Clusters of blue- or black-staining, bipolar chromatin condensations in large mononuclear cells in granulation tissue infected with Klebsiella (Calymmatobacterium granulomatis).

Donovan bodies

The microscopic appearance caused in cell scrapings from the genital region in the tropical sexually transmitted disease GRANULOMA INGUINALE. The Donovan bodies are seen in stained mononuclear cells and are caused by the infecting agent Donovania granulomatis . (Lt Col. Charles Donovan, 1863–1951, Irish physican).

Donovan bodies

Rod-shaped oval organisms found in tissue samples from patients with granuloma inguinale. Donovan bodies appear deep purple when stained with Wright's stain.
Mentioned in: Granuloma Inguinale

Donovan,

Charles, English surgeon, 1863-1951.
Donovan bodies - clusters of blue or black staining, bipolar chromatin condensations in large mononuclear cells in granulation tissue infected with Calymmatobacterium granulomatis.
Leishman-Donovan body - see under Leishman
References in periodicals archive ?
Evaluation date of suspected cases of kala-azar and response to treatment (SAG) Parameters Cases (n=6) 1 2 3 4 Fever (> 2 wk) Present Present Present Present Spleen Palpable Palpable Palpable Palpable Liver Palpable Palpable Not Palpable Palpable Aldehyde test +ve +ve +ve -ve LD bodies ND +ve +ve ND rK39 ND ND +ve ND Malaria parasite -ve -ve -ve -ve Treatment response Cured Cured Cured Cured 5 6 Fever (> 2 wk) Present Present Spleen Palpable Palpable Liver Palpable Palpable Aldehyde test +ve +ve LD bodies ND ND rK39 +ve ND Malaria parasite -ve -ve Treatment response Cured Cured ND, not done; LD bodies, Leishman Donovan bodies
A clinical hypothesis can be confirmed in the laboratory by the discovery of Donovan bodies in the fragment of the lesion, using cytodiagnosis or pathoanatomical exams.
Remaining techniques will be used in cases which have a limited number of Donovan bodies, such as happens when lesions have a shortened period of evolution or in cases in which patients previously used antibiotics [20,25,36].