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Donath-Landsteiner test

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Donath-Landsteiner test [do´nath land´sti-ner]
a test for paroxysmal hemoglobinuria based on the fact that the blood of patients with this disease contains isohemolysin and autohemolysin that unites with erythrocytes only at low temperatures (2° to 10°C), hemolysis occurring only after warming with the complement to 37°C.


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1) In most cases plasma is sufficient, except, for example, in some adsorption studies and would be necessary in testing that required complement such as the Donath-Landsteiner test.
The unique biphasic nature of this condition can be demonstrated in vitro using the Donath-Landsteiner test.
 
 
 
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