Donath-Landsteiner test

Donath-Landsteiner test

 [do´nath land´sti-ner]
a test for paroxysmal hemoglobinuria based on the fact that the blood of patients with this disease contains isohemolysin and autohemolysin that unites with erythrocytes only at low temperatures (2° to 10°C), hemolysis occurring only after warming with the complement to 37°C.
References in periodicals archive ?
1) In most cases plasma is sufficient, except, for example, in some adsorption studies and would be necessary in testing that required complement such as the Donath-Landsteiner test.
The unique biphasic nature of this condition can be demonstrated in vitro using the Donath-Landsteiner test.