Dolly


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The name of a sheep famous for being the first mammal cloned from an adult somatic cell. Dolly was grown from an egg, the nucleus of which had been replaced with the DNA from the mammary tissue of a six-year-old ewe

Dolly

the first mammal, a sheep, to be created by the cloning of an adult cell by NUCLEAR TRANSFER (see also ASEXUAL REPRODUCTION). The nucleus from a quiescent (see QUIESCENCE), adult udder cell of a finn Dorset ewe was transferred into an unfertilized OVUM from which the nucleus had been removed i.e. an enucleate OOCYTE, of a Scottish Blackface ewe. Electric current was applied to induce EMBRYO formation and the embryo introduced into a surrogate Blackface ewe. The process was repeated 276 times.

A lamb was born, called Dolly, to the Blackface ewe, but with almost identical genetic make-up to the finn Dorset ewe from which the genetic material derived.

The creation of Dolly demonstrated that adult cells could be reprogrammed for embryo development.

Dolly developed ARTHRITIS at the relatively young age of 5.5 years, and at 6 years was euthanased, due to development of a progressive lung disease. Whether this was a consequence of the cloning process is unknown.

References in classic literature ?
continued Dolly, holding back her sobs, "to get a letter.
Dolly, dearest, I do understand," said Anna, pressing her hand.
Dolly interrupted, gazing intently into her sister-in-law's face.
and here Anna guessed what would touch Dolly most) "he's tortured by two things: that he's ashamed for the children's sake, and that, loving you--yes, yes, loving you beyond everything on earth," she hurriedly interrupted Dolly, who would have answered-- "he has hurt you, pierced you to the heart.
Darling Dolly, I understand, but don't torture yourself.
But, Dolly, darling, I fully realize your sufferings, only there is one thing I don't know; I don't know.
No," Dolly was beginning, but Anna cut her short, kissing her hand once more.
Oh, of course," Dolly interposed quickly, as though saying what she had more than once thought, "else it would not be forgiveness.
Silas said "Good-bye, and thank you kindly," as he opened the door for Dolly, but he couldn't help feeling relieved when she was gone-- relieved that he might weave again and moan at his ease.
Macey and Dolly Winthrop, Silas spent his Christmas-day in loneliness, eating his meat in sadness of heart, though the meat had come to him as a neighbourly present.
GREEN activists tried to kidnap Dolly the sheep, it's been revealed.