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Related to Dolly: Dolly shop, Dolly Parton
The name of a sheep famous for being the first mammal cloned from an adult somatic cell. Dolly was grown from an egg, the nucleus of which had been replaced with the DNA from the mammary tissue of a six-year-old ewe


the first mammal, a sheep, to be created by the cloning of an adult cell by NUCLEAR TRANSFER (see also ASEXUAL REPRODUCTION). The nucleus from a quiescent (see QUIESCENCE), adult udder cell of a finn Dorset ewe was transferred into an unfertilized OVUM from which the nucleus had been removed i.e. an enucleate OOCYTE, of a Scottish Blackface ewe. Electric current was applied to induce EMBRYO formation and the embryo introduced into a surrogate Blackface ewe. The process was repeated 276 times.

A lamb was born, called Dolly, to the Blackface ewe, but with almost identical genetic make-up to the finn Dorset ewe from which the genetic material derived.

The creation of Dolly demonstrated that adult cells could be reprogrammed for embryo development.

Dolly developed ARTHRITIS at the relatively young age of 5.5 years, and at 6 years was euthanased, due to development of a progressive lung disease. Whether this was a consequence of the cloning process is unknown.

References in classic literature ?
Macey and Dolly Winthrop, Silas spent his Christmas-day in loneliness, eating his meat in sadness of heart, though the meat had come to him as a neighbourly present.
Lute saw Dolly check and rear in the air again, and caught up just as the mare made a second bolt.
But Dolly swerved from the road and dashed down a grassy slope yellowed with innumerable mariposa lilies.
He began with a brave muscular display as he lifted his leg over, but ended, on his feet, leaning against the limp Dolly for support.
They went back to the horses, where they subjected Dolly to a rigid examination that disclosed nothing.
It is more likely some evil, I don't know what, that Dolly has done.
Isla Kerr is thrilled to have Dolly back home - and reckons Father Christmas has worked his magic.
Staffordshire bull terrier Dolly, three, came to the Dogs Trust Merseyside centre as a pregnant stray and gave birth to six puppies.
Transwestern today announces prominent industry professional Matthew Dolly joined the firm s New Jersey office as director of research.
com is delighted to introduce a new colourful transport dolly to its expanding range of box accessories.
Dolly Parton excited many fans who have heard she would perform at the Glastonbury Festival.
COUNTRY superstar Dolly Parton was back in Newcastle to wow her fans.