Dohle bodies

Döh·le bod·ies

discrete round or oval bodies ranging in diameter from just visible to 2 mcm, which stain sky blue to gray blue with Romanowsky stains, found in neutrophils of patients with infections, burns, trauma, pregnancy, or cancer.

Döhle bodies

[Paul Döhle, Ger. pathologist, 1855–1928]
A leukocyte inclusion in the periphery of a neutrophil. It is composed of liquefied endoplasmic reticulum and is frequently accompanied by toxic granulations. Döhle bodies are present in association with burns, severe or systemic infections, exposure to cytotoxic agents, uncomplicated pregnancy, trauma, and neoplastic diseases.


(Doehle), Karl G.P., German histologist and pathologist, 1855-1928.
Döhle bodies - found in neutrophils of patients with infections, burns, trauma, pregnancy, or cancer. Synonym(s): Döhle inclusions; leukocyte inclusions
Döhle inclusions - Synonym(s): Döhle bodies
Döhle-Heller aortitis - a common manifestation of tertiary syphilis, involving the thoracic aorta, where destruction of elastic tissue in the media results in dilation and aneurysm formation. Synonym(s): syphilitic aortitis
References in periodicals archive ?
The previous patient slide had Dohle bodies, but they were also hard to read.
9] cells/L) (90% neutrophils), with toxic granulation, left shift, and Dohle bodies on the peripheral blood smear.
WBC Toxic granulations 28 Dohle bodies 5 Vacuolations 38 Smudge cells 32 Clefted lymphocytes 10 Hairy projections 2 Auer rods 2 RBC Anisocytosis 54 Poikilocytosis 31 Microcytosis 7 Macrocytosis 2 Hypochromasia 3 Polychromasia 35 Echinocytes (burr cells) 19 Dacrocytes (teardrops) 16 Spherocytes 6 Target cells 2 Acanthocytes 1 Ovalocytes 28 Schistocytes 5 Stomatocytes 2 Howell-Jolly bodies 1 Basophilic stipplings 5 Platelet Clumped platelets 3 Platelet satellitosis 5 Large platelets 8 Giant platelets 8 Overall Cell Morphology Code Concordance, Overall Type % Concordance, % WBC Toxic granulations 78.
The abundant cytoplasmic inclusions in neutrophilic leukocytes (black arrow) morphologically resemble Dohle bodies, which are frequently found in macrothrombocytopenias, such as May-Hegglin anomaly (1).
Polychromasia and fine basophilic stippling were present in the red cells, and occasional Dohle bodies were seen within the neutrophils.
The presence of dohle bodies, toxic granulation, and vacuolization are important indicators of bacterial infection and sepsis.
Additionally, neutronphils exhibited toxic granulation, dohle bodies, and vacuolization, all of which indicated the presence of an infection.
Toxic changes such as vacuolisation and the presence of Dohle bodies occur in infectious diseases and have been associated with high levels of CRP.
Medical technologists are able to view a cell class together and/or transport images via their network, which helps to better evaluate hyper-segmented toxic granulation, dohle bodies, and vacuoles in the neutrophils, thereby reducing technologist time in processing hematology results.
The smear showed 56% band forms, complete with dohle bodies, vacuoles, and toxic granulation.
Subsequent review of the peripheral smear may indicate the presence of a new invader with rising neutrophil band forms, toxic granulation, and dohle bodies.