Dobrava Virus

A distinct regional member of the Hantavirus group isolated from a rodent reservoir, the yellow-necked field mouse (Apodemus flavicollis), found in Eastern Europe
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Among the related viruses of the DOBV species, Sochi virus seems to have the highest level of virulence, similar to Dobrava virus (carried by A.
Hantaan virus and its related strains, Seoul virus, Dobrava virus, and Puulmala virus, cause Korean hemorrhagic fever (KHF) in the Far East; hemorrhagic fever with renal syndrome (HFRS), nephrosonephritis, or Tula fever in Russia and China; and nephropathia epidemica (NE) in Scandinavia.
Identification of genetic evidence for Dobrava virus spillover in rodents by nested reverse transcription (RT)-PCR and TaclMan RT-PCR.
The last possible limitation is that serum samples from PUUV-infected patients cross-react strongly with Sin Nombre virus and weakly with Hantaan virus, Seoul virus, and Dobrava virus (36,37).
1 Puumala virus IgG ND Negative ND ND ND Immunoblot Puumala virus IgM ND Positive# ND ND ND Immunoblot Dobrava virus IgG ND Negative ND ND ND Immunoblot Dobrava virus IgM ND Negative ND ND ND Immunoblot Hantaan virus IgG ND Negative ND ND ND Immunoblot Hantaan virus IgM ND Negative ND ND ND Immunoblot * Bold font indicates positive results.
HFRS is caused by the prototypic hantavirus Hantaan and by Dobrava virus, Puumala virus (PUUV), and Seoul virus in Eurasia; HCPS is caused by Andes virus, Sin Nombre virus and related hantaviruses in the Americas.
Puumala virus (PUUV), Dobrava virus (DOBV), and Seoul virus cause different forms of hemorrhagic renal syndrome (1,2).
Isolation of Dobrava virus from Apodemus flavicollis in Greece.
Several lineages of Dobrava virus circulate in Europe and Russia (3-6), and are named according to their rodent reservoirs: Apodemus flavicollis (Dobrava-Af), A.
Thirty cases of hemorrhagic fever with renal syndrome (HFRS) due to Puumala virus (PUUV), Saaremaa virus (SAAV), and Dobrava virus infection were confirmed in Estonia.
Cao Bang virus (CBNV TC-3), EF543526; Hantaan virus (HTNV 76-118), NC_005219; Seoul virus (SEOV 80-39), NC_005237; Soochong virus (SOOV SC-1), AY675353; Dobrava virus (DOBV Greece), NC_005234; Puumala virus (PUUV Sotkamo), NC_005223; Prospect Hill virus (PHV PH-1), X55129; Tula virus (TULV Moravia 5302v), NC_005228; Sin Nombre virus (SNV NMH10), NC_005215, and Andes virus (ANDV Chile-9717869), NC_003467.
Hantaan virus (HTNV) shares a multimillennium relationship with the striped field mouse (Apodemus agrarius), Dobrava virus (DOBV) with the yellow-necked field mouse (Apodemus flavicollis), Seoul virus (SEOV) with the Norway rat (Rattus norvegicus), Thailand virus (THAIV) with the bandicoot rat (Bandicota indica), Puumala virus (PUUV) with the bank vole (Myodes glareolus, formerly Clethrionomys glareolus), Tula virus (TULV) with the European common vole (Microtus arvalis), Prospect Hill virus (PHV) with the meadow vole (M.