topoisomerase

(redirected from Dna topoisomerases)
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topoisomerase

 [to″po-i´so-mer-ās]
an enzyme involved in mobilization and replication of DNA during cell division.

to·po·i·so·mer·ase

(tō'pō-i-som'ĕr-ās),
A type of enzyme converting (isomerizing) one topologic version of DNA into another; acts by catalyzing the breakage and reformation of DNA phosphodiester linkages.
[topo- + isomerase]

topoisomerase

(tō′pō-ī-sŏm′ə-rās′, -rāz′)
n.
Either of two isomerase enzymes that alter the topology of DNA molecules by breaking and reconnecting coiled strands.

topoisomerase

[to′po-i′so-mer-ās]
an enzyme involved in mobilization and replication of DNA during cell division.

topoisomerase

an enzyme involved in DNA replication that introduces a single-strand nick in the DNA enabling it to swivel and thereby relieve the accumulated winding strain generated during unwinding of the double helix.
References in periodicals archive ?
Secondary metabolites as DNA topoisomerase inhibitors: a new era towards designing of anticancer drugs.
Fluorescence spectroscopy studies of vaccinia type IB DNA topoisomerase.
Ribonuclease activity of vaccinia DNA topoisomerase IB: kinetic and high-throughput inhibition studies using a robust continuous fluorescence assay.
DNA topoisomerases are nuclear enzymes that are the targets for several anticancer drugs.
DNA topoisomerases as targets of therapeutics: an overview.
Untangling the double helix; DNA entanglement and the action of the DNA topoisomerases.
Cytotoxic and DNA topoisomerases I and II inhibitory constituents from the roots of Aralia cordata.
They describe DNA super-coiling, including its quantitative measure and the geometrical properties of closed- circular DNA, the behavior of DNA on surfaces, knots and catenanes, DNA topoisomerases, and the biological consequences of DAN topology, including genome organization, replication, control of gene expression, transcription, and recombination.