The ADAM (a disintegrin
and metalloproteinase) family, a subgroup of the metzincin metalloproteinase superfamily, plays an important role in physiologic processes, such as cell migration, cell fusion, fertilization and immune response (8,9).
When stimulated there is an increase in cell expression in the chondrocytes of several matrix metalloproteinases (MMPs) such as MMP 1, 3 and 13, and prostaglandin E-2 (PGE-2), and aggrecanases such as a disintegrin
and metalloproteinase with thrombospondin motif 4 (ADAMTS-4).
Different up-regulated proteins during the disease include insulin growth factor (IGF) II, a disintegrin
and metalloproteases (ADAM) 9, signal transducers and activators of transcription (STAT) 3, suppressors of cytokine signalling (SOCS) 3, and cyclin D1 while the down-regulated proteins during the disease include collagen I, SMAD 4, fragile histidine triad (FHIT), and SOCS1.
2005) The disintegrin
ADAM9 indirectly contributes to the physiological processing of cellular prion by modulating ADAM10 activity.
2]-antiplasmin; TAT,thrombin-antithrombin; PAP, plasmin- [alpha] 2-antiplasmin complex; TM,thrombomodulin; ADAMTS13, a disintegrin
and metalloproteinase with thrombospondin motifs 13.
Alzheimers disease; ADAM-10, A Disintegrin
and metalloproteinase domain-containing protein 10; APP, Amyloid precursor protein; APPswe.
sup] Two other targets of miR-29 (A disintegrin
and metalloprotease [ ADAM ] 12 and ADAM19 ) were reported to be effectors that antagonized TGF-[sz] signaling-induced renal fibrosis.
Alpha-secretase activity of the disintegrin
metalloprotease ADAM 10 Influences of domain structure.
and metalloproteinase with thrombospondin motifs 4 (ADAMTS4), which takes part in connective tissue degradation, is expected to be involved in a pivotal biological pathway for building up marbling.
Subsequently, these large multimers undergo proteolytic degradation by metalloprotease ADAMST-13 (a disintegrin
and metalloprotease with thrombospondin type 1 motifs), which cleaves the molecule in domain A2 to produce circulating VWF of various multimer sizes (10,11).
Thrombotic thrombocytopenic purpura (TTP) is a rare, life-threatening disorder that occurs due to deficiency of ADAMTS13 (a disintegrin
and metalloproteinase with a thrombospondin type 1 motif, member 13), which is a von Willebrand factor (VWF) cleaving protein.
and metalloprotease 33 (ADAM33) gene polymorphisms and the risk of asthma: a meta-analysis.