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diphthamide

   Also found in: Wikipedia 0.01 sec.
diphthamide
an amino acid residue formed by post-translational modification of histidine. There is ADP-ribosylation of elongation factor 2 (EF2) protein; the mode of action of diphtheria toxin whereby translation of mRNA is blocked.


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In contrast to bacterial EF2, eEF2 and EF2 from archaea contain a unique and strictly conserved posttranslationally modified histidine referred to as diphthamide (9).
 
 
 
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