DPP4

(redirected from Dipeptidyl peptidase 4)

DPP4

A gene on chromosome 2q24.3 that encodes dipeptidyl-peptidase 4, a ubiquitous, membrane-bound enzyme with roles in nutrition, metabolism, the endocrine system, immune regulation (for instance, it is essential for T-cell receptor (TCR)-mediated T-cell activation), bone marrow mobilisation, apoptosis, cell adhesion and tumourigenesis.
References in periodicals archive ?
Dipeptidyl peptidase 4 is a functional receptor for the emerging human coronavirus-EMC.
High and growing diabetes population in the country, rising obese and geriatric population, and rapid market adoption of drugs from the classes such as Dipeptidyl Peptidase 4 (DPP-4) inhibitors, Glucagon-Like Peptide (GLP)-1, Sodium-Glucose Transport Proteins (SGLT-1) and others would drive the anti-diabetes market in the forecast period.
Inhibition of dipeptidyl peptidase 4 by BI-1356, a new drug for the treatment of beta-cell failure in type 2 diabetes.
43% added reduction in their hemoglobin A1, level, compared with patients on sitagliptin, a dipeptidyl peptidase 4 (DDP-4) inhibitor, in a multicenter, randomized study with 447 patients.
In the recently completed 12 week Phase IIb clinical trial in 494 patients with type 2 diabetes mellitus (T2DM), 'Melogliptin', Glenmark's investigational medicine from a new class of diabetes treatments called dipeptidyl peptidase 4 (DPP-4) inhibitors, improved glycemic control in patients with type 2 diabetes mellitus and exhibited excellent safety and tolerability profile.
Both compounds inhibit an enzyme called dipeptidyl peptidase 4 (DPP-4), which usually controls the body's production of a hormone, called GLP1.
The Company has pioneered the field of dipeptidyl peptidase 4 (DP4)-inhibition for the treatment of type 2 diabetes.
The dipeptidyl peptidase 4 (DPP-4) inhibitor, in a single 5-mg tablet formulation, is indicated for improving blood glucose control in adults with type 2 diabetes in combination with diet and exercise.

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