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dioxygenases |
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dioxygenases enzymes which incorporate both atoms of O2 into one substrate. Less common than mono-oxygenases. Important example is the 15-15′-dioxygenase enzyme in the small intestine which cleaves plant carotenoids containing provitamin A activity, such as β-carotene, into retinal. This enzyme is absent from felines, such as the cat, and is the reason cats are dependent on animal sources of vitamin A. How to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit webmaster's page for free fun content. |
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Indeed, the similarity in effects of Ni(II), hypoxia, and the inhibitor of 2OG-dependent dioxygenases (dimethyloxalytglycine) suggests that iron and 2OG-dependent dioxygenases are involved in regulation of both pathways. |
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