az·ole ( z  l ,  zl)n. A class of organic compounds having a five-membered heterocyclic ring with two double bonds; pyrrole. |
azole
Infectious disease One of a family of synthetic broad-spectrum antifungal antibiotics–including ketoconazole, fluconazole, itraconazole Indications Various azoles have established efficacy in treating blastomyocosis, candidiasis,
coccidioidomycosis, cryptococcosis, histoplasmosis, paracoccidoidomycosis and sporotrichosis Adverse effects N&V, anorexia, rash, pruritus, nonspecific ↑ liver enzymes, anemia, leukopenia, thrombocytopenia, headache, etc Drug interactions
Plasma levels of azoles are ↓ by antacids, H2-receptor antagonists, sucralfate, isoniazid, phenytoin, rifampin. See Fluconazole, Itraconazole, Ketoconazole.
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