diosgenin


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di·os·gen·in

(dī-os'jen-in),
A steroid sapogenin found in the roots of plants such as the yam; its steroid portion serves as a source from which pregnenolone and progesterone can be prepared.
Synonym(s): nitogenin

diosgenin

Herbal medicine
A steroid saponin closely related to human sex hormones, corticosteroids, vitamin D and cardiac glycosides, which is present in wild yam (Dioscorea species) and Beth root (Trillium erectum). Diosgenin is used for the commercial synthesis of cortisone, pregnenolone, progesterone and other steroids.
References in periodicals archive ?
Diosgenin was extracted and purified as reported previously.
Diosgenin, a naturally occurring furostanol saponin, suppresses 3-hydroxy-3-methylglutaryl CoA reductase expression and induces apoptosis in HCT-116 human colon carcinomacells.
Chen, "In vivo protective effects of diosgenin against doxorubicin-induced cardiotoxicity," Nutrients, vol.
Structure-function relationship for saponin effects on cell cycle arrest and apoptosis in the human 1547 osteosarcoma cells: a molecular modelling approach of natural molecules structurally close to diosgenin.
Solasodine A3/4- sitosterol diosgenin [6 7] triterpenes [8] steroidal saponins [9] and steroidal glycoalkaloids [10-12] are also reported from the fruit.
Variation in diosgenin level in seed kernels among different provenances of Balanites aegyptiaca Del (Zygophyllaceae) and its correlation with oil content.
Diosgenin ameliorates cognition deficit and attenuates oxidative damage in senescent mice induced by D- galactose.
Other spice-derived phytochemicals, such as capsaicin, cardamonin, dibenzoylmethane, diosgenin, gambogic acid, gingerol, thyoquinone, urosolic acid and zerumbone have been show the ability to suppress NF-kB activation in a similar manner.
Diosgenin in fenugreek is a steroidal sapogenin and is one of the compounds of fenugreek extract which acts as cortisone, and consequently, reduces anxiety (19).
Wild yam contains the glycoside diosgenin, which has been shown to have an anaboliclike effect or the ability to increase muscle mass (18) Licorice root acts as an adaptogen and also has anti-inflammatory properties.
A phytoestrogen (plant estrogen) called diosgenin found in wild yams can be converted in a laboratory into progesterone.
Diosgenin was used as a standard and the results obtained were expressed as mg diosgenin equivalent per g of sample dry matter.