Dioctyl


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docusate sodium

Apo-Docusate Sodium (CA), Colace, Correctol, Correctol Stool Softener (CA), Diocto, Dioctyl (UK), Docusol (UK), Dom-Docusate Sodium (CA), D.O.S. Softgels, Docu-Soft, DOK, D-S-S, DulcoEase (UK), Dulcolax Stool Softener, Enemeez, Genasoft Softgels, Norgalax (UK), Novo Docusate (CA), PHL-Docusate Sodium (CA), PMS-Docusate Sodium, Ratio-Docusate Sodium (CA), Selax (CA), Silace

Pharmacologic class: Emollient

Therapeutic class: Stool softener, surfactant

Pregnancy risk category C

Action

Increases absorption of liquid into stool, resulting in softening of fecal mass. Also promotes electrolyte and water secretion into colon.

Availability

docusate calcium

Capsules: 240 mg

Capsules (soft gels): 240 mg

Rectal solution: 283 mg/5 ml

docusate sodium

Capsules: 50 mg, 100 mg, 250 mg

Capsules (soft gels): 100 mg, 250 mg

Liquid: 150 mg/15 ml

Syrup: 50 mg/15 ml, 60 mg/15 ml, 20 mg/5 ml, 100 mg/30 ml, 150 mg/15 ml

Tablets: 100 mg

Indications and dosages

Stool softener

Adults and children older than age 12: 240 mg (docusate calcium) or 50 to 200 mg (docusate sodium) P.O. daily until bowel movements are normal

Children ages 6 to 12: 40 to 120 mg (docusate sodium) P.O. daily

Children ages 3 to 6: 20 to 60 mg (docusate sodium) P.O. daily

Contraindications

• Hypersensitivity to drug
• Abdominal pain, nausea, or vomiting
• Intestinal obstruction

Precautions

Use cautiously in:
• pregnant or breastfeeding patients.

Administration

• Give tablets and capsules with full glass of water.
• Give liquid solution with milk or fruit juice.
• Be aware that excessive or long-term use may lead to laxative dependence.

Adverse reactions

EENT: throat irritation

GI: nausea, diarrhea, mild cramps

Skin: rash

Other: bitter taste, decreased appetite, laxative dependence

Interactions

Drug-drug.Mineral oil: increased mineral oil absorption, causing toxicity

Warfarin: decreased warfarin effects (with high doses)

Patient monitoring

• If diarrhea occurs, withhold drug and notify prescriber.
• Know that therapeutic efficacy usually becomes apparent 1 to 3 days after first dose.

Patient teaching

• Instruct patient to drink sufficient fluids with each dose and to increase fluid intake during the day.
• Advise patient to prevent constipation by increasing fluids and consuming more dietary fiber (as in fruits and bran).
• Inform patient that excessive or prolonged use may lead to laxative dependence.
• As appropriate, review all other significant adverse reactions and interactions, especially those related to the drugs mentioned above.

Dioctyl

A brand name for DOCUSATE SODIUM.
References in periodicals archive ?
When the chain length of alkoxy group of the adipates continues to increase, such as dihexyl adipate, didecyl adipate and dioctyl adipate, can depress the saturation vapor pressure lower than that of gasoline, among which dihepyl adipate is the most effective one.
This capacity upgrade will specifically benefit producers of medical devices and flooring that are looking for alternatives to replace the conventional plasticisers, dioctyl phthalate (DOP) and diisononyl phthalate (DINP).
9:2 size fractions of weight ratio); and (2) tristearin, particles, with 80-120 dioctyl sulfosuccinate and and 200-400 nm diameters phosphatidylcholine (1:1:0.
The active molecule, Dioctyl sodium sulfosuccinate, is available in laxatives for human internal use.
Eastman DOTP, dioctyl terephthalate, offered as a replacement for DOP and similar plasticizers in applications requiring improved durability, good electrical properties, and improved automotive fogging resistance.
GREENGUARD Children & Schools Certification specifically limits emissions of total phthalates, consisting of dibutyl (DBP), diethylhexyl (DEHP), diethyl (DEP), dimethyl (DMP), butylbenzyl (BBP), and dioctyl (DOP) phthalates.
aeruginosa was mainly due to the phycoconstitutent dioctyl phthalate.
Surfactant, Triton GR-7M (anionic surfactant based on dioctyl sulfosuccinates), obtained from Dow Chemical, was used in selected coating formulations.
Mn salts Zr salt Additives Hydroquinone Hydroquinone MTBHQ Dioctyl adipate Tempo Foodpack 2 Resin Co-resin Vegetable alkyd 1 vegetable oil 2 Solvent White mineral oil (n-paraffinic FDA-A approved) No more alkyl-benzene Dryer Zr salt Additives MTBHO
PA is a raw material for the production of dioctyl phthalate (DOP), which is added to PVC (polyvinylchloride) and PU (polyurethane) as softening agent to enhance ease of shaping.