Morgan's findings provide strong evidence that inhaled diketone vapors can produce airway fibrotic disease and support a causal relationship between workplace exposure to high concentrations of diketones and the development of bronchiolitis obliterans, according to John Morris, a professor of pharmacology and toxicology at the University of Connecticut, Storrs.
Caption: Engineering controls such as ventilated mixing vessels with hinged lids or access ports are the first line of protection against worker exposures to diketones in flavorings.
The vicinal diketones (VDKs), diacetyl and pentanedione, are secondary by-products of the biosynthetic pathway for valine and isoleucine, respectively.
Influence of Wort Amino Acid Levels on Vicinal Diketone Production in Lager Fermentations
This can be associated with modifications in the chemical environment of the carbonyl bonds and also to a possible formation of [Beta] enolized diketone
A MA model product with the diketone structure but without curable group was also synthesized for the mechanistic study.
It was inferred that the substituted [beta]-diketone underwent photolysis during exposure and the diketone structure was broken down.