dihydrofolate reductase

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enzyme catalyzing the conversion of folate to 5,6,7,8-tetrahydrofolate, which is the key carrier of one-carbon units in purine and pyridime synthesis, the pathway for the breakdown of histidine and the synthesis of S-adenosylmethionine from S-adenosylhomocysteine. This enzyme is the target for methotrexate, which inhibits enzyme action, a key means of inducing remissions in acute leukemias.

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aditoprim alpha-adrenergic antagonist amethopterin aminopterin antagonist antifolate chemotherapy antimetabolite beta-adrenergic antagonist Daraprim DHFR folic acid gene amplification gene expression gene library gene pool gene probe gene splicing Gene transcription gene transfer			Recent work demonstrated that EGCG reduced dihydrofolate reductase activity, which would affect nucleic acid and protein synthesis. Mechanisms of cancer prevention by green and black tea polyphenols by Life Extension Pemetrexed is an antifolate/antimetabolite with several molecular targets involved in both pyrimidine and purine neosynthesis: thymidylate synthase (TS), dihydrofolate reductase (DHFR) and glycinamide ribonucleotide formyltransferase (GARFT). A randomized Phase II trial of pemetrexed plus irinotecan (ALIRI) ... by Gullen-Ponce, Carmen; Carrato, Alfredo / Advances in Gastrointestinal Cancer Dihydrofolate reductase is required for the growth of actively dividing cells. For Rheumatoid Arthritis Sufferers... Some Info About Methotrexate by Nathan Wei / Health care industry community			diglossia diglyceride dignathus dignified life closure Dignitas Clinic digoxigenin digoxin digoxin immune Fab DiGuglielmo's syndrome digyny dihematoporphyrin ether diheterozygote dihybrid dihybrid cross dihydrate dihydric dihydric alcohol dihydro- dihydro-orotate dihydrocodeine dihydrocodeine bitartrate dihydrocodeinone dihydroergotamine dihydroergotamine mesylate dihydrofolate dihydrofolate reductase dihydrofolic acid dihydroindolone dihydrolipoic acid dihydropteroic acid dihydropyrimidine dehydrogenase (NADP) dihydrostreptomycin dihydrotachysterol dihydrotestosterone dihydroxy dihydroxyacetone dihydroxyaluminum dihydroxyanthraquinone dihydroxycholecalciferol dihydroxycoumarin glycoside dihydroxyphenylalanine diiodide diiodohydroxyquin diiodohydroxyquinoline diiodotyrosine diisocyanate diisopropyl phosphorofluoridate diketone diketopiperazine dikkop dikoor			dihybrid dihybrid cross dihybrid cross dihybrids dihybrids dihydrate dihydrate dihydrate dihydrazone dihydric dihydric dihydric alcohol dihydric alcohol dihydro- dihydro- dihydro-orotate Dihydroartemisinin Dihydroartemisinin-Piperaquine Dihydrochalcone dihydrochloride Dihydrocodeine Dihydrocodeine dihydrocodeine bitartrate Dihydrocodeinone Dihydrodiol Dehydrogenase 3 Dihydroergotamine Dihydroergotamine Dihydroergotamine mesylate Dihydroergotamine-Sandoz Dihydrofolate dihydrofolate reductase dihydrofolic acid Dihydrogen Dihydrogen Dihydrogen Dihydrogen dioxide Dihydrogen dioxide Dihydrogen dioxide Dihydrogen hexachloroplatinate (IV) hexahydrate Dihydrogen monoxide Dihydrogen monoxide closet Dihydrogen Monoxide Research Division Dihydrogen phosphate Dihydrogen phosphate Dihydrogen phosphate Dihydrogen sulfate Dihydrogen sulfate Dihydrogen sulfate Dihydrogen sulphate Dihydrogen sulphate Dihydrogen sulphate Dihydrogenated Tallow Dimethylammonium Chloride Dihydrogren monoxide Dihydrogren monoxide Dihydrogren monoxide Dihydrogren monoxide Dihydrogren monoxide Dihydroheptaprenol Dihydrohydrooxycodeinone Dihydrohydrooxycodeinone Dihydrohydroxycodeinone

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