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dihydrofolate

   Also found in: Wikipedia 0.02 sec.
dihydrofolate /di·hy·dro·fo·late/ (DHF) (-fo´lāt) an ester or dissociated form of dihydrofolic acid.


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MTX is a structural analog of folic acid that can competitively inhibit the binding of dihydrofolic acid to the enzyme dihydrofolate reductase.
Wegener granulomatosis: a case report and update by Berney, Seth Mark / Southern Medical Journal
Dihydrofolate reductase (DHFR) catalyzes the reduction of dihydrofolate to tetrahyrofolate using coenzyme nicotinamide adenine dinucleotide phosphate (NAPD) as a proton donor.
Chemistry and Chemical Engineering by Journal of the Mississippi Academy of Sciences
Novel aspects of resistance to drugs targeted to dihydrofolate reductase and thymidylate synthase.
Prediction of toxicant-specific gene expression signatures after ... by Perou, Charles M. / Environmental Health Perspectives
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