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dihydrofolate

   Also found in: Wikipedia 0.01 sec.
dihydrofolate /di·hy·dro·fo·late/ (DHF) (-fo´lāt) an ester or dissociated form of dihydrofolic acid.


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The design, implementation and broad applications of this strategy are illustrated with a large number of enzymes with particular detail provided for the example of murine dihydrofolate reductase (DHFR).
This vector contains a human [beta]-globin gene whose expression is controlled by elements of the globin hypersensitive region, and a mutant form of dihydrofolate reductase (DHFR) for use as a selectable marker.
In addition, a number of new drug classes such as dihydrofolate reductase inhibitors (DHFR) are under evaluation which are effective in multi drug resistant organisms.
 
 
 
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