dihydrofolate

dihydrofolate

/di·hy·dro·fo·late/ (DHF) (-fo´lāt) an ester or dissociated form of dihydrofolic acid.
References in periodicals archive ?
The researchers found triclosan to affect growth of the malaria parasite by inhibiting an enzyme called dihydrofolate reductase (DHFR) at the blood stage.
Methotrexate (MTX) is a folic acid analogue and a competitive inhibitor of dihydrofolate reductase (DHFR)3.
Molecular docking was used to illustrate interaction among components within the active sites of dihydrofolate reductase (DHFR).
MTX promotes the inhibition of DNA replication by inhibiting dihydrofolate reductase that is involved in the synthesis of thymidylate, purines, methionine, and serine (18).
We also identified 2 nonsynonymous SNPs in the dihydrofolate reductase homologue.
The dockings of these molecules in the active sites of lanosterol demethylase, dihydrofolate reductase and topoisomerase II indicate their strong interactions with these enzyme [23].
Treatment with Methotrexate (MTX), an antimetabolite chemotherapeutic agent that binds to the enzyme dihydrofolate reductase, which is involved in the synthesis of purine nucleotides, this interferes with DNA synthesis and disrupts cell multiplications, achieves results comparable to surgery for treatment of appropriately selected ectopic pregnancies.
similar to p-aminobenzoic acid (PABA) which is part of dihydrofolate.
20], the antibody productivity and the product quality of the cell pools with different LC:HC ratios using the IRES-based tricistronic vectors containing LC, HC, and the dihydrofolate reductase (DHFR) genes were examined.
coli dihydrofolate reductasetrimethoprim, a drug-receptor system," Proteins: Structure, Function, and Bioinformatics, 4 (1), 31-47, 1988.
pylori by inhibiting DNA gyrase (a crucial enzyme for bacterial replication and transcription) and dihydrofolate reductase enzyme blockage.
From 2004 to 2006, he participated in the assessment of the pharmacodynamics and pharmacokinetics of the novel dihydrofolate reductase inhibitor, JPC2056, and its principal active metabolite JPC2067 in cynomolgus monkeys using an in vivo-in vitro (ex vivo) model.