Didronel


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Didronel

 [di-dro´nel]
trademark for preparations of etidronate disodium, a bone calcium regulator.

etidronate disodium

Didronel, Didronel PMO (UK)

Pharmacologic class: Bisphosphonate

Therapeutic class: Bone resorption inhibitor, hypocalcemic agent

Pregnancy risk category B

Action

Blocks calcium absorption, slowing bone metabolism and reducing bone resorption and formation

Availability

Tablets: 200 mg, 400 mg

Indications and dosages

Paget's disease

Adults: 5 to 10 mg/kg P.O. daily as a single dose for up to 6 months, or 11 to 20 mg/kg P.O. daily for up to 3 months

Heterotopic ossification after hip replacement

Adults: 20 mg/kg P.O. daily for 1 month before and 3 months after surgery

Heterotopic ossification in spinal cord injury

Adults: Initially, 20 mg/kg P.O. daily for 2 weeks, decreased to 10 mg/kg P.O. daily for 10 weeks

Dosage adjustment

• Decreased glomerular filtration rate

Contraindications

• Hypersensitivity to drug or its components
• Abnormalities of esophagus, such as stricture or achalasia, that delay esophageal emptying
• Osteomalacia

Precautions

Use cautiously in:
• renal impairment, long bone fractures, active upper GI condition (such as Barrett's esophagus, dysphagia, other esophageal diseases, gastritis, duodenitis, or ulcers)
• pregnant or breastfeeding patients
• children (safety not established).

Administration

• Give with 6 to 8 oz of water 2 hours before first meal.
• Make sure patient doesn't eat for 2 hours after receiving dose.
• Know that therapy longer than 3 months is not recommended.

Adverse reactions

GI: nausea, constipation, stomatitis, diarrhea, esophageal irritation

Metabolic: hyperphosphatemia

Musculoskeletal: bone pain and tenderness, fractures, osteonecrosis of the jaw

Skin: rash

Interactions

Drug-drug.Warfarin: increased prothrombin time

Drug-diagnostic tests.Serum phosphorus: increased level

Patient monitoring

• Monitor fluid intake and output.
• Monitor patient for GI discomfort. Divide doses as needed to ease symptoms.
• Assess bowel pattern. If constipation occurs, increase fluids and administer stool softeners, as prescribed.
• Closely monitor renal function tests and serum phosphorus level.

Patient teaching

• Instruct patient to take drug first thing in morning on an empty stomach, with 6 to 8 oz of water only and to stay upright for at least 30 minutes afterward.
• Instruct patient not to take drug with food because of decreased drug absorption.
• Tell patient not to consume highcalcium products, such as milk or antacids, or vitamins and mineral supplements high in calcium, iron, magnesium, or aluminum, within 2 hours of taking dose.

Tell patient to immediately discontinue drug and notify prescriber if severe chest pain, difficulty or painful swallowing, or new or worsening heartburn occurs.
• Advise patient to report bone pain or decreased range of motion.
• As appropriate, review all other significant adverse reactions and interactions, especially those related to the drugs and tests mentioned above.

Didronel

(dĭ-drō′nəl)
A trademark for the drug etidronate disodium.

Didronel

a trademark for a calcium regulator (etidronate disodium).

Didronel®

Etidronate, see there.

Didronel

A brand name for ETIDRONATE.
References in periodicals archive ?
Resection of heterotopic ossification and Didronel therapy-regaining wheelchair independence in the spinal cord injured patient.
Didronel (etidronate; Warner Chilcott/Pfizer/Sumitomo Pharma)
1) The fractures are associated with long-term use of bisphosphonates, which are sold under the brand names Actonel, Aredia, Boniva, Didronel, Fosamax, Reclast, Skelid, and Zometa.
Currently FDA-approved bisphosphonates, including Fosamax (alendronate), Actonel (risedronate), Didronel (etidronate), Boniva (ibandronate), and Reclast (Zometa) (zoledronate), are designed to strengthen bone by inhibiting normal osteoclastic bone resorbing activity, which slows the loss of bone mineral density (BMD), allowing the trabecular architecture to stabilize.
How many pages had we printed out, about Zoladex, Tamoxifen, Quadramet, pamidronate drips, Didronel IV infusions, Xeloda, Herceptin, Taxol, Arimidex?
The use of three phase bone scan in the early diagnosis of heterotopic ossification and in the evaluation of Didronel therapy.
The company has one of the strongest portfolios of trusted, quality, leadership brands, including Actonel(R), Asacol(R), Crest(R), Didronel PMO(R), Fibresure(R), Intrinsa(R), Metamucil(R), Oral-B(R), Pepto-bismol(R), Thermacare(R), Vicks(R), Pampers(R), Ariel(R), Always(R), Pantene(R), Herbal Essences(R), Mach3(R), Fairy(R), Ace(R), Lenor(R), M.
Calcium (and Vitamin D) supplements can help with osteoporosis, but the most effective treatments are hormone replacement therapy (HRT), and a family of drugs called bisphosphonates (such as Didronel and Fosamax).
I still have problems, but at least I've managed to get rid of the stress fractures by taking a drug called Didronel, which alters the bone metabolism.
Could didronel, prescribed for my osteoporosis, be the cause?
Labeling changes and the Medication Guide will not apply to bisphosphonates used for Paget's disease or cancer/hypercalcemia such as Didronel, Zometa, Skelid, and their generic products.
There are three drugs of this type licensed to treat osteoporosis in Britain - Fosamax, Didronel and Actonel - and others are being researched.