Dichloroacetate (DCA), a non-patented compound, counteracts a protective mechanism used by cancer cells that prevents glucose products from entering mitochondria, which would send the mitochondria into overdrive, resulting in cell death.
For instance, the codrug Bet-CA (a chemical combination of dichloroacetate and betulinic acid) increases ROS production and significantly alters mitochondrial membrane potential gradient ([DELTA][PSI]m), followed by the release of Cyt C which prompts cells to undergo mitochondria mediated apoptosis .
dichloroacetate (DCA), AZD7545 and radicicol), the pyruvate analog DCA is the most common classic inhibitor of PDK isoforms, (49) although it has clinically symptomatic side effects of peripheral neuropathy.
RC1 is non-stereospecific dehalogenase that can act on D-2-chloropropionate (D-2-CP), L-2-chloropropionate (L-2-CP), 2,2-dichloropropionate (2,2-DCP), trichloroacetate (TCA), dichloroacetate (DCA) and monochloroacetate (MCA).
Both groups received intravenously: 10% glucose solution (250ml) plus matrine 150 mg/day, 10% glucose solution (250ml) plus compound diisopropylamine dichloroacetate and 10% glucose solution (250ml) plus hepatocyte growth-promoting factor 100 mg/day, treatment group received plus Entecavir 0.