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Diabinese |
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Diabinese, trademark for an oral antidiabetic (chlorproPAMIDE). chlorpropamide Warning - High-alert drug! Apo-Chlorpropamide (CA), Chloronase (CA), Diabinese, Novo-Propamide (CA) Pharmacologic class: Sulfonylurea Therapeutic class: Hypoglycemic Pregnancy risk category C ActionUnclear. Thought to reduce blood glucose level primarily by stimulating secretion of endogenous insulin from pancreatic beta cells. AvailabilityTablets: 100 mg, 250 mg ⊘Indications and dosages ➣ To lower glucose level in patients with non-insulin-dependent (type 2) diabetes mellitus Adults: 250 mg P.O. daily with breakfast, increased as necessary to a maximum dosage of 750 mg daily ➣ To convert from insulin therapy to oral hypoglycemic therapy Adults: For patient on 40 units of insulin or less, stop insulin and start chlorpropamide at 250 mg P.O. daily. If patient is receiving more than 40 units of insulin, start chlorpropamide at 250 mg P.O. daily, with insulin dosage reduced 50%; further insulin decreases depend on patient response. Dosage adjustment• Renal impairment Off-label uses• Diabetes insipidus Contraindications• Hypersensitivity to drug PrecautionsUse cautiously in: Administration• Give before meals for best results.
Adverse reactionsCNS: paresthesia, fatigue, dizziness, vertigo, malaise, headache CV: increased risk of CV mortality EENT: tinnitus GI: nausea, heartburn, epigastric distress GU: tea-colored urine Hematologic: leukopenia, thrombocytopenia, aplastic anemia, agranulocytosis, hemolytic anemia Hepatic: cholestatic jaundice Metabolic: dilutional hyponatremia, prolonged hypoglycemia Skin: rash, pruritus, erythema, urticaria Other: hypersensitivity reaction, disulfiram-like reaction InteractionsDrug-drug. Anabolic steroids, chloramphenicol, clofibrate, guanethidine, MAO inhibitors, salicylates, sulfonamides: increased hypoglycemia Beta-adrenergic blockers: prolonged hypoglycemia Corticosteroids, glucagons, rifampin, thiazide diuretics: decreased hypoglycemic response Hydantoins: increased hydantoin blood level Oral anticoagulants: increased hypoglycemic activity Drug-diagnostic tests. Alanine aminotransferase, alkaline phosphatase, aspartate aminotransferase, bilirubin, blood urea nitrogen, cholesterol, creatinine, lactate dehydrogenase: increased levels Glucose, granulocytes, hemoglobin, platelets, sodium, white blood cells: decreased values Drug-herbs. Bitter melon, burdock, dandelion, eucalyptus, ginkgo, marshmallow: increased hypoglycemic activity Drug-behaviors. Alcohol use: altered glycemic control (most commonly leading to hypoglycemia), disulfiram-like reaction Patient monitoring• Assess serum electrolyte levels before starting therapy. Patient teaching• If patient takes drug once daily, instruct him to take dose before breakfast. If he takes it more than once daily, advise him to take doses before meals. How to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit webmaster's page for free fun content. |
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Generic name Brand name acetohexamide Dymelor chlorpropamide Diabinese glimepiride Amaryl glipizide Glucotrol, Glucotrol XL glyburide DiaBeta, Glynase, PresTab, Micronase tolazamide Tolinase tolbutamide Orinase Find Your Diabetes Medicines(*) Sulfonylureas Amaryl DiaBeta Diabinese Dymelor Glucotrol Glucotrol XL Glynase PresTab Micronase Orinase Tolinase Biguanides Glucophage Alpha-glucosidase Inhibitors Glyset Precose Thiazolidinediones Rezulin Meglitinides: Prandin Insulins Lispro (Humalog) Regular Premixed Ultralente NPH or Lente |
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