Wolfram Syndrome (redirected from Diabetes Insipidus & Mellitus with Optic Atrophy and Deafness)

Wolfram syndrome

[wool′frəm]

Etymology: D.J. Wolfram, American physician, 20th century

an autosomal-recessive syndrome, first evident in childhood, consisting of diabetes mellitus, diabetes insipidus, optic atrophy, and neural deafness. Also called DIDMOAD syndrome.

---

Wolfram Syndrome

An autosomal recessive [MIM 222300] condition characterised by diabetes insipidus, non-autoimmune type 1 diabetes mellitus, optic atrophy, sensorineural deafness and further neurological and endocrinological abnormalities. Death occurs prematurely, often from respiratory failure associated with brainstem atrophy