Wolfram syndrome

(redirected from Diabetes Insipidus & Mellitus with Optic Atrophy and Deafness)

DIDMOAD syndrome

acronymic syndrome of diabetes insipidus, diabetes mellitus, optic atrophy, and deafness, of uncertain cause.
Synonym(s): Wolfram syndrome

Wolfram syndrome

[wool′frəm]
Etymology: D.J. Wolfram, American physician, 20th century
an autosomal-recessive syndrome, first evident in childhood, consisting of diabetes mellitus, diabetes insipidus, optic atrophy, and neural deafness. Also called DIDMOAD syndrome.
An autosomal recessive [MIM 222300] condition characterised by diabetes insipidus, non-autoimmune type 1 diabetes mellitus, optic atrophy, sensorineural deafness and further neurological and endocrinological abnormalities. Death occurs prematurely, often from respiratory failure associated with brainstem atrophy

Wolf·ram syn·drome

(wulf'răm sin'drōm)
A disorder consisting of diabetes insipidus, diabetes mellitus, optic atrophy, and deafness; the genetic abnormality is located on chromosome 4p; autosomal recessive inheritance.

Wolfram,

Donald J., U.S. physician, 1910–.
Wolfram syndrome - autosomal recessive disorder characterized by juvenile diabetes mellitus and optic atrophy. The acronym DIDMOAD is used to describe the syndrome (diabetes insipidus, diabetes mellitus, optic atrophy and deafness).
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