erythroleukemia (redirected from Di Guglielmo's disease)

erythroleukemia /eryth·ro·leu·ke·mia/ (e-rith?ro-loo-ke´me-ah) a malignant blood dyscrasia, one of the myeloproliferative disorders, with atypical erythroblasts and myeloblasts in the peripheral blood.

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e·ryth·ro·leu·ke·mi·a (-rthr-l-km-)

n.

A malignant disorder characterized by the proliferation of erythroblastic and leukoblastic tissues.

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erythroleukemia

a malignant blood dyscrasia of dogs and cats; one of the myeloproliferative disorders, with atypical erythroblasts and myeloblasts in the peripheral blood.

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erythroleukemia Di Guglielmo syndrome Hematology An acute myelocytic leukemia–FAB classification, M6, which is usually acquired affecting the elderly, but rarely also AD Clinical Anemia, fever, hepatosplenomegaly, hemorrhagic diathesis Lab ↑ Erythroblasts in circulation, BM, ↑ gammaglobulins, false positive positive rheumatoid factor, ANA, Coombs antiglobulin Genetics Aneuploidy–63%; cytogenetic defects, especially chromosomes 5 and 7 Prognosis Poor. Cf French-American-British classification.