USP46

(redirected from Deubiquitinating enzyme 46)

USP46

A gene on chromosome 4q12 that encodes a deubiquitinase of the C19 peptidase family which plays a role in psychological behaviour, possibly by regulating GABA activity. USP46 is thought to deubiquitinate GAD1/GAD67; it has little activity by itself, requiring interaction with WDR48 to have a high activity.
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