USP15

(redirected from Deubiquitinating enzyme 15)

USP15

A gene on chromosome 12q14 that encodes an enzyme which deubiquitinates Lys-48-linked polyubiquitinated proteins, targeting them against proteasomal degradation. USP15 protects APC and HPV type-16 protein E6 against degradation via the ubiquitin proteasome pathway. It is expressed in skeletal muscle, kidneys, heart, placenta, liver, thymus, lungs and ovaries.