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desmosomes

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desmosomes,


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Examination of tumor cells on electron microscopy will reveal (1) desmosomes, (2) arrays of cytoplasmic, uniformly dispersed microfilaments in the presence or absence of dense bodies, and (3) pinocytotic vesicles with basal lamina separating the tumor cells from the stroma.
Among the topics are cadherins, adherens junctions and desmosomes, integrins and focal contacts, receptor tyrosine phosphatases, Notch and Slit-Robo signaling, adhesive binding to collagen and fibrillin, and complex adhesive mechanisms involved in leukocyte migration and malaria.
Remarkably, DSC3 and PKP1, components of desmosomes, have been reported to be highly upregulated in squamous cell carcinomas.
 
 
 
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