DSG1

(redirected from Desmosomal Glycoprotein 1)
Also found in: Acronyms.

DSG1

A gene on chromosome 18q12.1 that encodes desmoglein 1, a calcium-binding transmembrane glycoprotein component of desmosomes in epithelial cells, which belongs to the cadherin cell adhesion molecule superfamily.

Molecular pathology
Desmoglein 1 is the antigen targeted in the autoimmune blistering disease pemphigus foliaceus; defects in DSG1 cause palmoplantar keratoderma striate type 1.