Desmosomes form the adhesive core of intercellular junctions, which consist of desmosomal Cadherins, desmogleins
(Dsgs), and desmocollins (figure 1).
are one of the major glycoproteins of the desmosomal structure found in epithelial cells.
Internalization of constitutive desmogleins
with the subsequent induction of desmoglein
2 in pemphigus lesions.
are calcium-binding transmembrane glycoproteins, members of the desmosomal cadherins that provide adhesive integrity to desmosomes between adjoining keratinocytes; They consist of proteins Dsg1, Dsg2, Dsg3, and Dsg4.
Nguyen VT, Ndove A, Shultz LD, Pittelkow MR, Grando SA: Antibodies against keratinocyte antigens other than desmogleins
1 and 3 can induce pemphigus vulgaris-like lesions.
Detection of IgA autoantibodies to desmogleins
by an enzyme-linked immunosorbent assay: the presence of new minor subtypes of IgA pemphigus.
Desmosomes consist of 2 desmosomal-specific cadherin family members desmogleins
(DSGs) and desmocollins (DSCs).
The binding of antibody to various desmogleins
may have a direct effect on desmosomal adherence or may trigger a cellular process that results in acantholysis.
Their transmembrane molecules are the desmosomal cadherins: desmogleins
and desmocollins (Nollet et al, 2000).
The classes of agents to be included under the agreement include peptide cadherin antagonist compounds for N-cadherin, E-cadherin, desmogleins
, VE-cadherin and OB-cadherin, as well as Adherex's third generation small molecule, non-peptide cadherin antagonists.
Autoantibody production in pemphigus vulgaris and pemphigus foliaceus is polyclonal, and most circulating autoantibodies against desmogleins
are of the IgG4 subclass.
Characterization of autoantibodies in pemphigus using antigen-specific ELISAs with baculovirus expressed recombinant desmogleins