The currently known target antigens are desmoglein 1 (Dsg1), desmoglein 3
(Dsg3), and plakin protein, which act as adhesion molecules between keratinocytes in the epidermis.
Autoantibodies are produced against desmoglein 3
or both desmoglein 1 and desmoglein 3
in pemphigus vulgaris.
132) However, over-expression of certain adhesion proteins, such as claudin 1 (133) and desmoglein 3
, (134) can enhance invasion.
, its pathogenecity and a possibility for therapeutic target in pemphigus vulgaris.
The underlying mechanism involves the formation of autoantibodies against the cadherin-type adhesion molecules desmoglein 3
Three such markers are Napsin A, Desmoglein 3
protein has been identified as the autoantigen of the autoimmune skin blistering disease pemphigus vulgaris and plays important roles in human squamous cell cancer.
Bu adezyon molekullerinden desmoglein 1 (Dsg1) ve desmoglein 3
(Dsg3) en iyi tanimlanmis olanlardir.
Blisters occur in the epidermis and the mucous membranes, where the IgG autoantibodies target two structural proteins of the desmosomes identified as desmoglein 1 (Dsg1) and desmoglein 3
1) In PF the autoantibody is to desmoglein 1 (Dsgl), in PV to desmoglein 3
Immunologic testing of this patient showed that in addition to antibodies against desmoglein 1, she began making high-titer auto-antibodies against desmoglein 3
and had transformed into PV
Markers Commonly Used for Separating Squamous Cell Carcinoma (SCC) From Adenocarcinoma (ADC) Antibody SCC ADC TTF1 + Napsin A - + p40 + - CK5/6 + - CK5 + - p63 - (diffuse pattern) - Desmoglein 3
+ - Abbreviations: CK, cytokeratin; TTF1, thyroid transcription factor 1; +, greater than 75% of cases are positive; -, less than 5% of cases are positive.