desmoglein

(redirected from Desmoglein 2)

desmoglein

(dĕz″mō-glē′ĭn)
A cell surface molecule typically found in desmosomes that makes skin cells adhere to each other. Autoantibody disruption of cellular adhesion by desmogleins results in pemphigus. Disruption of desmogleins by staphylococcal toxins is responsible for the blistering of the skin seen in staphylococcal scalded skin syndrome.
References in periodicals archive ?
Most variants associated with ARVC occur in genes encoding desmosomal proteins [plakophilin 2 (PKP2), desmocollin 2 (DSC2), desmoglein 2 (DSG2), desmoplakin (DSP), junction plakoglobin (JUP)] (9).
5% muscle 1 DCM TTN Titin 13%-27% MYH7 Myosin, heavy chain 7 [congruent to] 5% LMNA Lamin A/C [congruent to] 5% DSP Desmoplakin [congruent to] 5% TNNT2 Troponin T2, cardiac type 2%-3% TPM1 Tropomyosin 1 (alpha) [congruent to] 2% TNNI3 Troponin I3, cardiac type <1% BAG3 BCL2 associated athanogene 3 N/A (a) RBM20 RNA binding motif protein 20 N/A ARVC PKP2 Plakophilin 2 25%-30% DSP Desmoplakin 9% DSG2 Desmoglein 2 3.
Internalization of constitutive desmogleins with the subsequent induction of desmoglein 2 in pemphigus lesions.