Northwestern Medicine and Tel Aviv University scientists' finding is linked to the team's identification of a new rare genetic disease, called 'severe dermatitis, multiple allergies, and metabolic wasting,' or SAM, caused by mutations in the molecule desmoglein 1.
Professor of Pathology and Toxicology at Northwestern University Feinberg School of Medicine, said that Desmoglein 1 is best understood as the 'glue' that holds the outer layer of human skin together.
In contrast, pemphigus foliaceus cases showed immunoreactivity for IgG4 in the intercellular junctions of superficial keratinocytes, reflecting the known location of desmoglein 1
(Figure 1, C).
Dermatology- BP180, BP230, desmoglein 1
& 3, Envoplakin & more.
Diagnosis of pemphigus by ELISA: a critical evaluation of two ELISAs for the detection of antibodies to the major pemphigus antigens, desmoglein 1
1) In PF the autoantibody is to desmoglein 1
(Dsgl), in PV to desmoglein 3 (Dsg3).
nin calismasi desmoglein 1
ve 3 icin gelistirilen ELISA testlerinin hastaligin aktifligi ile dogru orantili bir iliski gosterdigini belirlemistir (35).
Endemic pemphigus foliaceus (EPF), or fogo selvagem, is a chronic autoimmune disease (1)fc characterized by the formation of intraepidermal blisters, which are attributed to the presence of immunoglobulin G4 (IgG4) and IgG1 autoantibodies against desmoglein 1 (2) that reduce the adhesion between keratinocytes.
This view is supported by the demonstration that in vitro induction of apoptosis in keratinocytes leads to the cleavage of desmoglein 1.
Bu adezyon molekullerinden desmoglein 1 (Dsg1) ve desmoglein 3 (Dsg3) en iyi tanimlanmis olanlardir.
Hanakawa Y, Matsuyoshi N, Stanley JR: Expression of desmoglein 1 compensates for genetic loss of desmoglein 3 in keratinocye adhesion.
Son yillarda, tani ve takipte kullanilmak uzere (ornegin desmoglein 1
, desmoglein 3, BP180, NC 16A, epidermal transglutaminaz gibi) ELISA ticari test sistemleri gelistirilmistir.