The currently known target antigens are desmoglein 1
(Dsg1), desmoglein 3 (Dsg3), and plakin protein, which act as adhesion molecules between keratinocytes in the epidermis.
Autoantibodies are produced against desmoglein 3 or both desmoglein 1
and desmoglein 3 in pemphigus vulgaris.
Staphylococcal exfoliative toxin B specifically cleaves desmoglein 1
4) ETs are serine proteases that bind to the cell adhesion molecule desmoglein 1
and cleave it, resulting in a loss of cell-cell adhesion which is the cause of the clinical manifestations.
Staphylococcus pseudintermedius exfoliative toxin EXI selectively digests canine desmoglein 1
and causes subcorneal clefts in canine epidermis.
Spink5-deficient mice mimic Netherton syndrome through degradation of desmoglein 1
by epidermal protease hyperactivity.
Intraepidermal splitting via the granular layer by the particular cleavage of desmoglein 1
, a desmosomal cadherin protein that mediates cell-cell adhesion of keratinocytes in the granular layer, occurs owing to the effects pronounced by these toxins.
Northwestern Medicine and Tel Aviv University scientists' finding is linked to the team's identification of a new rare genetic disease, called 'severe dermatitis, multiple allergies, and metabolic wasting,' or SAM, caused by mutations in the molecule desmoglein 1
In contrast, pemphigus foliaceus cases showed immunoreactivity for IgG4 in the intercellular junctions of superficial keratinocytes, reflecting the known location of desmoglein 1
(Figure 1, C).
The proteins associated with desmosomes namely desmoglein 1
and 3 are affected in this condition wherein auto-antibodies are directed against these proteins.
Dermatology- BP180, BP230, desmoglein 1
& 3, Envoplakin & more.
Diagnosis of pemphigus by ELISA: a critical evaluation of two ELISAs for the detection of antibodies to the major pemphigus antigens, desmoglein 1