dense granule

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dense granule

Cardiology
A specialised spherical storage and secretory vesicle in platelets which contains ADP, ATP, ionised calcium, pyrophosphate and serotonin. Reduced-platelet dense-granule secretion is associated with marked protection against arterial thrombosis, inflammation, and neointimal hyperplasia after vascular injury in a mouse model.

Pathology
Dense-core granules, see there.
References in periodicals archive ?
When released, alpha granules, dense granules, and lysosomes secrete their contents to assist in the adhesion of segregation of platelets.
In the resting state, platelets have a smooth discoid shape and contain cytoplasmic organelles, cytoskeletal elements, platelet-specific alpha and dense granules and an invaginating open-cannalicular phospholipid membrane.
By contrast, gamma-irradiated tachyzoites group showed vacuolization in their cytoplasm with the substantial reduction in the number of dense granules and the blur of some organelles.
During invasion and creation of the PV membrane, apically oriented organelles called micronemes and rhoptries are discharged, followed later by release of dense granules content (DG).
Juxtaligamental cell cytoplasm contains numerous electron dense granules that are believed to release substances that affect the interaction between the extracellular matrix molecules and cause rapid changes in the mechanical properties of the connective tissue in response to stimuli from the nervous system (Wilkie and Emson, 1987; Wilkie.
9 In addition to the surface receptors, 20,000-40,000 molecules of aIIbb3 are also present in the a-granules, dense granules and on the membranes of open canalicular system of the platelets.
Our products are dense granules impregnated with flavor," says company founder Mark Weiser.
The commonly reported mechanisms are decreased life span of platelets due to immunological and non-immunological mechanisms, elevated macrophage colony stimulating factors causing platelet destruction; ultra structural changes like centralization of dense granules, glycogen depletion, formation of pseudopods, and micro aggregation; consumption by diffused intravascular coagulation (DIC) host oxidative stress through oxidization of membrane lipids causing changes in fluidity and permeability of the cell membrane and its effect on fragility (2,3).
GRA antigens are stored within Toxoplasma dense granules and secreted into the Parasitophorous Vacuole (PV) after parasite invasion (19), (20).
Human platelets are secretory cells, and exocytosis is the mode of secretion which results in the release of a-granules, lysosomes and dense granules.