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denileukin diftitox |
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denileukin diftitox /den·i·leu·kin dif·ti·tox/ (den?i-loo´kin dif´ti-toks) a genetically engineered construct combining amino acid sequences for specific diphtheria toxin fragments linked to sequences for interleukin-2 (IL-2); used as an antineoplastic. |
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| The investigators concluded that the novel combination of denileukin diftitox and rituximab has significant clinical activity in this heavily pretreated population, with toxicities that can be managed with premedications and close monitoring. Protein synthesis inhibition reflects the efficiency with which the diphtheria toxin portion of denileukin diftitox is internalized in cancerous cells. In a second, related study, Tufts scientists reported that in vitro, chronic lymphocytic leukemia (CLL) cells that were exposed to bexarotene were more susceptible to treatment with denileukin diftitox than were cells treated with denileukin diftitox alone. |
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denileukin diftitox
