methyltransferase

(redirected from Demethylase)
Also found in: Wikipedia.

methyltransferase

 [meth″il-trans´fer-ās]
any enzyme that catalyzes transmethylation.

meth·yl·trans·fer·ase

(meth'il-trans'fer-ās),
Any enzyme transferring methyl groups from one compound to another.

methyltransferase

/meth·yl·trans·fer·ase/ (-trans´fer-ās) any of a group of enzymes that catalyze the transfer of a methyl group from one compound to another.

meth·yl·trans·fer·ase

(meth'il-trans'fĕr-ās)
Any enzyme transferring methyl groups from one compound to another.
Synonym(s): transmethylase.

methyltransferase

any enzyme that catalyzes transmethylation.
References in periodicals archive ?
According to the company, IMG-7289 is a small molecule developed by inhibits lysine-specific demethylase 1 (LSD1 or KDM1A), an enzyme regulating gene expression in hematopoietic cells.
Virtual screening of (1a) and (2b) against DNA gyrase, topoisomerase-IV, lanosterol-14-alpha demethylase, cyclooxygenase-2 and epidermal growth factor receptor tyrosine kinase gives total energy values upto -405.
Hence, further study should be done to increase the developmental capacity of cloned embryos by enhancement of nuclear reprogram ability of donor cells and embryos in combination with other factors such as histone deacetylase inhibitor [25] and removal of H3K9me3 in donor somatic cells by ectopically expressed H3K9me3 demethylase such as Kdmd [28].
Background: The human Ubiquitously transcribed tetratricopeptide repeat gene, Y-linked (UTY) gene encodes histone demethylase involved in protein-protein interactions.
Itraconazole is highly keratophilic and lipophilic triazole which impairs fungal cell wall synthesis by inhibiting cytochrome P 450 dependent 14 alpha lanosterol demethylase enzyme and interferes with fungal ergosterol synthesis7.
The dockings of these molecules in the active sites of lanosterol demethylase, dihydrofolate reductase and topoisomerase II indicate their strong interactions with these enzyme [23].
In search for epigenomic modifiers that control adipose tissue function and also impact on T2D pathogenesis, we have recently identified the transcriptional coregulators GPS2 (G-Protein Pathway Suppressor 2) and KDM6B (Histone Lysine Demethylase 6B, also called JMJD3) as strong candidates.
These strategies include the targeting of the histone demethylase jumonji, AT rich interactive domain 1B (JARID1B), which we found to be functionally significant in the maintenance of cancer stem cells.
Other mechanisms such as alteration or up-regulation of target enzyme, demethylase, have also been suggested.
450] dependent 14-[alpha] demethylase (CYP51A1), which converts lanosterol into ergosterol.
Efinaconazole is an azole-class drug that interferes with ergosterol biosynthesis by blocking lanosterol demethylase.
There are findings indicating that the molecular pathology in KS is caused by mutations in genes involved in histone modification and responsible for the production of histone methyltransferase and histone demethylase (MLL2 and KDM6A, respectively).