CCR5

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CCR5

A gene on chromosome 3p21.31 that encodes a member of the beta chemokine receptor family, which is similar to G protein-coupled receptors. CCR5 is expressed by T cells and macrophages; it is a receptor for various CC-chemokines, including MIP-1-alpha, MIP-1-beta and RANTES, and transduces a signal by increasing the intracellular calcium ion level. CCR5 may play a role in the control of granulocytic lineage proliferation or differentiation, and is an important co-receptor for macrophage-tropic viruses (e.g., HIV-1) entering host cells.

CCR5

A chemokine receptor; defects in its structure caused by genetic mutation cause the progression of AIDS to be prevented or slowed.
Mentioned in: AIDS
References in periodicals archive ?
According to MedicalXpress, Kan and his team preferred a solution on recreating the effects of CCR5 delta 32 mutation in pluripotent stem cells which may lead to the possibility of engineering HIV resistance on every cell type.
Since one of the effects of the research is to replicate CCR5 delta 32 mutation found in a limited number of people Europe, certain risks must be considered.
Mutation risks other than CCR5 delta 32 is not yet confirmed at this time as the research continues to develop.
Studies conducted in mouse models of WNV infection clearly demonstrate that in the presence of the delta 32 mutation, far fewer of these lymphocytes are present in brain tissue, reflecting inhibition of the cell-mediated host immune response to the viral pathogen, the neurologist explained.
Homozygosity for CCR5 delta 32 was shown to confer powerful protection against HIV infection in exposed individuals.
Research by geneticist Stephen O'Brien has traced Crohn's Delta 32 mutation back hundreds of years to towns like Eyam, where the defensive genetic mutation held off the black death in much the same way it now protects Crohn from HIV.
Crohn learned about Delta 32 after he was enrolled in a 1994 Aaron Diamond AIDS Research Center study of a dozen HIV-exposed individuals who remained seronegative over long periods of time.
Subsequent research has shown that some LTNPs are heterozygous for the CCR5 mutation, called "CCR5 delta 32," i.
It replicates the known genetic factor called CCR5 delta 32 that prevents HIV to attach itself with immune cells and render it unable to replicate in the body.
16 on Black Elk Energy Offshore Operations LLC's platform located at West Delta 32 Block, in the Gulf of Mexico 17 miles southeast of Grand Isle, LA.