neoplasm(redirected from Degree of differentiation)
Also found in: Dictionary, Thesaurus, Encyclopedia.
Related to Degree of differentiation: Neoplastic cells
neoplasm/neo·plasm/ (ne´o-plazm) tumor; any new and abnormal growth, specifically one in which cell multiplication is uncontrolled and progressive. Neoplasms may be benign or malignant.
neoplasm(1) An abnormal mass of tissue, the growth of which exceeds and is uncoordinated with that of normal tissue, and persists in the same excessive manner after cessation of the stimuli evoking the change.
(2) Any autonomous proliferation of cells, benign or malignant.
• Behavior—Benign, borderline or malignant.
• Degree of differentiation—Well differentiated (i.e., the neoplastic cell simulates its parent or progenitor cell) or poorly differentiated (i.e., the neoplastic cell is bizarre and “ugly”, as defined by pathologic criteria).
• Embryologic origin—Epithelial (e.g., adenocarcinoma, squamous cell carcinoma), lymphoproliferative (e.g., leukaemia, lymphoma), mesenchymal (e.g., sarcoma).
• Gross appearance—Well circumscribed or infiltrative: benign neoplasms are usually slow growing, well circumscribed, often with a fibrous capsule, and are symptomatic only if they compromise a confined space (e.g., massive meningioma of the cranial cavity, or encirclement of vital blood vessels); malignancies are often aggressive with increased mitotic activity, bizarre cells, necrosis and invasion of adjacent structures, and have metastatic potential.
neoplasmOncology 'An abnormal mass of tissue, the growth of which exceeds and is uncoordinated with that of normal tissue and persists in the same excessive manner after cessation of the stimuli evoking the change'; an autonomous proliferation of cells, benign or malignant. See Cancer, Doubling time, Intraductal papillary-mucinous neoplasm of pancreas, Metastases, Papillary & solid neoplasm of pancreas.
Synonym(s): tumor (2) .
neoplasmA collection of cells, derived from a common origin, often a single cell, that is increasing in number and expanding or spreading, either locally or to remote sites. A tumour. Neoplasms may be BENIGN or MALIGNANT. The term literally means a new growth. See also CANCER.
neoplasman autonomous growth of tissue in the body which has no apparent physiological function, such as a TUMOUR.
neoplasmbenign or malignant lesion formed as a distinct mass of neoplastic tissue; characterized by partial/total lack of normal structural organization/functional coordination with normal tissues at that site; Table 1
|Benign||Seborrhoeic warts (basal cell papilloma)||Slow-growing, clearly demarcated, pigmented, 'stuck-on' dermal lesions that may form skin tags, occurring especially around the neck in obese individuals|
|Premalignant||Solar keratoses||Slow-growing pink/grey-brown scaly epidermal lesions occurring in sun-exposed|
|skin (dorsa of hands, lower leg, face, bald pate) in subjects >60 years of age; lesions should be regularly monitored as they may undergo malignant changes|
|Bowen's disease||Intraepidermal carcinoma (epithelioma) presenting as a small, slow-growing scaly plaque that can become nodular or ulcerate if the lesion extends into the dermis; these lesions should be removed or treated with a topical chemotherapeutic agent such as 5-fluorouracil|
|Malignant||Squamous cell carcinoma||Keratotic, scaly, elevated or nodular lesion with a depressed centre that may ulcerate, arising in sun-exposed skin; these lesions must undergo biopsy as they may metastasize|
|Basal cell carcinoma (rodent ulcer)||Low-grade malignant lesion due to a locally invasive epidermal tumour, with a pearly raised edge and a tendency to central ulceration; these lesions must be biopsied as they may metastasize|
|Malignant melanoma||Virulent skin tumour, with 30% of incidence involving lower limb, most commonly occurring after 40 years of age in areas of sun-exposed or non-sun-exposed skin; lesions classically are raised, itchy, may bleed and show an irregular border and irregular pigmentation and/or Hutchinson's sign; these lesions must be biopsied as they may metastasize|
Patient discussion about neoplasm
Q. What is a brain tumor?
Q. Is this a tumor? I felt a lump in my breast a few days ago in the shower. Is this a Tumor? Help! I'm scared.
Q. what is carcinoid tumors? I had my appendix removed and the doctor came in the room very shocked and said it was full of carcinoid tumors. Im scared to get them somewhere else.