Efficacy of deferoxamine
in animal models of intracerebral hemorrhage: a systematic review and stratified meta-analysis," PLoS ONE, vol.
Comparison of deferoxamine
pharmacokinetics between asymptomatic thalassemie children and those exhibiting severe neurotoxicity.
Using the iron-depleting agents, deferoxamine
and ferrostatin-1, the cytotoxic activity was diminished, which is another proof for ferroptosis as relevant cell death mode of artemisinin compounds.
Randomized phase II trial of deferasirox (Exjade, ICL670), a once-daily, orally-administered iron chelator, in comparision to deferoxamine
in thalassemia patients with transfusional iron overload.
and deferiprone both iron chelators are used now a days but they are very expensive and difficult to use and have many side effects.
Medical standard: Iron-removal is accomplished by weekly phlebotomy of 1-2 units (250-500 mL of blood, each of which removes 250 mg of iron), and deferoxamine
chelation is used in patients who cannot tolerate phlebotomy.
The use of deferoxamine
therapy is limited by cost as well as the need for parenteral therapy, discomfort, inconvenience, and neurotoxicity.
Visual and auditory neurotoxicity in patients receiving subcutaneous deferoxamine
There are six agents available to treat heavy metal (arsenic, gold, iron, lead, and mercury) intoxication: de-ferasirox (iron), deferoxamine
(iron), dimercaprol (arsenic, gold, lead, and mercury), edetate calcium disodium (lead), penicillamine (copper and mercury), and succimer (lead).
Reversal of cardiac complications by deferiprone and deferoxamine
combination therapy in a patient affected by a severe type of juvenile haemochromatosis (JH).
Effects of allopurinol and deferoxamine
on reperfusion injury of the brain in newborn piglets after neonatal hypoxia-ischemia.
Patients with thalassemia intermedia were started on DFX if they refused deferoxamine
(DFO) or they were on hydroxyurea.