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deferoxamine |
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deferoxamine /de·fer·ox·amine/ (dĕ″fer-oks´ah-mēn) an iron-chelating agent isolated from Streptomyces pilosus; used as the mesylate salt as an antidote in iron poisoning. deferoxamine, desferrioxamine an iron chelating compound used as the mesylate to treat iron poisoning. deferoxamine Deferoxamine mesylate Hematology A trihydroxamic acid produced by Streptomyces pilosus that ↑ urinary iron excretion; it is the only FDA-approved iron-chelating agent for clinical use; early use of deferoxamine in
thalassemia major ↓ transfusion-related iron overload and protects against DM, cardiac disease, early death. See Hemochromatosis. How to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit webmaster's page for free fun content. |
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Exploring the "iron shuttle" hypothesis in chelation therapy: effects of combined deferoxamine and deferiprone treatment in hyper transfused rats with labeled iron stores and in iron-loaded rat heart cells in culture. The patient received frequent blood transfusions and monthly intravenous deferoxamine for secondary hemochromatosis. Among the recognizable risk factors for the development of RCM are poorly controlled diabetes, hematologic malignancies, acquired immunodeficieney syndrome, severe bums, renal diseases, malnutrition, iatrogenic immunosuppression after organ transplantation, and deferoxamine therapy. |
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