defensin


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defensin

/de·fen·sin/ (de-fen´sin) any of a group of small antimicrobial cationic peptides occurring in neutrophils and macrophages.

defensin

[difen′sin]
a peptide with natural antibiotic activity found within human neutrophils. Three types of defensins have been identified, each consisting of a chain of about 30 amino acids. Similar molecules occur in white blood cells of other animal species. They show activity toward viruses and fungi, in addition to bacteria.

defensin

A small (29 to 34 amino acid) cationic peptide produced in neutrophils and epithelial cells, which may be involved in nonspecific response to microbes.

Types
ß-defensin 1—expressed in alveolar epithelia of normal individuals, but not in patients with cystic fibrosis.
ß-defensin 2—first identified in the skin of patients with psoriasis who have a decreased susceptibility to skin infections.

defensin

(dē-fĕn′sĭn) [term coined by Robert I. Lehrer, U.S. physician, b. 1938]
Destructive peptides (groups of amino acids) found in the granules of neutrophils and other phagocytic cells that kill bacteria and fungi by destroying their membranes. Defensins are active against bacteria, fungi, and enveloped viruses in vitro. They may contribute to host defenses against susceptible organisms.
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References in periodicals archive ?
Defensin of the zebra mussel (Dreissena polymorpha): molecular structure, in vitro expression, antimicrobial activity, and potential functions.
Though the researchers used a single defensin for most of their experiments, their work with a handful of others suggests that all defensins are similar enough to share this capability.
19, 2014 /PRNewswire/ -- Zimmer today announced Synovasure PJI Alpha Defensin Test for Periprosthetic Joint Infection, the first and only test specifically designed for the diagnosis of Periprosthetic Joint Infection (PJI), is now eligible for sale in several European countries after earning key overseas certification this month.
Heliomicin is an antifungal defensin peptide previously isolated from hemolymph of H.
4] Human genes: ACTB, actin, beta; B2M, beta-2-microglubulin; DEFA3, defensin, alpha 3, neutrophil-specific; SRGN, serglycin; HBB, hemoglobin, beta; UROD, uroporphyrinogen decarboxylase; ITGA2B, integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41); ITGB3, integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61); CD34, CD34 molecule; CD3E, CD3e molecule, epsilon (CD3-TCR complex); CD4, CD4 molecule; CD8A, CD8a molecule; CD19, CD19 molecule.
Novel insect defensin mediates the inducible antibacterial activity in larvae of the dragonfly Aeschna cyanea (Paleoptera, Odonata).
It suppresses the body's production of a particular antimicrobial, human beta defensin 1, which is in the stomach lining.
By sequencing the genetics of the amino acids in defensin, they found that all it took was a change in a single gene to turn the defensin into a poison.
Defensin exerts an antimicrobial effect by breaking the hydrophobic core of the lipid bilayer on microbes (Oren et al.
Human A-defensin 1 (hBD-1) is one of the most prominent peptides of its class but comparison with other defensins suggested only minor antibiotic killing activity.
1 duplication syndrome differentiated from copy number variation of the defensin cluster at prenatal diagnosis in four new families.