defensin


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defensin

/de·fen·sin/ (de-fen´sin) any of a group of small antimicrobial cationic peptides occurring in neutrophils and macrophages.

defensin

[difen′sin]
a peptide with natural antibiotic activity found within human neutrophils. Three types of defensins have been identified, each consisting of a chain of about 30 amino acids. Similar molecules occur in white blood cells of other animal species. They show activity toward viruses and fungi, in addition to bacteria.

defensin

A small (29 to 34 amino acid) cationic peptide produced in neutrophils and epithelial cells, which may be involved in nonspecific response to microbes.

Types
ß-defensin 1—expressed in alveolar epithelia of normal individuals, but not in patients with cystic fibrosis.
ß-defensin 2—first identified in the skin of patients with psoriasis who have a decreased susceptibility to skin infections.

defensin

(dē-fĕn′sĭn) [term coined by Robert I. Lehrer, U.S. physician, b. 1938]
Destructive peptides (groups of amino acids) found in the granules of neutrophils and other phagocytic cells that kill bacteria and fungi by destroying their membranes. Defensins are active against bacteria, fungi, and enveloped viruses in vitro. They may contribute to host defenses against susceptible organisms.
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References in periodicals archive ?
23) Topical defensin that has been formulated to penetrate into hair follicles, where the LGR6+ stem cells reside, has been demonstrated to render a smoother, more youthful appearance to the skin.
Besides enhancing chemotaxis and phagocytic capabilities of innate immune cells, [11] the complex of calcitriol, VDR, and retinoid X receptor directly activates the transcription of antimicrobial peptides such as defensin [beta]2 (DEFB) and cathelicidin antimicrobial peptide (hCAP18).
Editor's Note: In animals that received high fat, vitamin D deficient diets, oral administration of synthetic defensin improved intestinal bacteria balance.
Structure-dependent charge density as a determinant of antimicrobial activity of peptide analogues of defensin.
Keywords: Allergic rhinitis, children, defensin, disease severity, nasal fluid, polyurethane
Expression of defensin like gene was intense due to combined influence of S.
In this paper, the isolation and biological properties of a flower derived defensin from Catharanthus roseus (white flower) and (pink flower) have been described.
Studies have revealed that number of antimicrobial peptides and inflammatory cytokines including CRP, interleukin (IL)-1, IL-6, IL-17A, interferon-a, tumor necrosis factor-a, defensin, cathelicidin LL-37, and so on in synovial fluid could be used as biomarkers for diagnosis.
Tenders are invited for Supply of (1 Mouse Monocional to beta 2 defensin antibody 100 pg