decorin


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decorin

A small proteoglycan that opposes the actions of transforming growth factor beta in connective tissues, esp. in the response to inflammation, injury, or scarring.

decorin

a small chondroitin sulfate proteoglycan found in bone, thought to be involved in the organization and mineralization of bone.
References in periodicals archive ?
The amount of decorin staining in subsinusoidal areas of tunica albuginea (SATA) and subsinusoidal areas of trabecular wall (SATW) are summarized in Table 1.
Last year we successfully incorporated Decorin into a membrane wound dressing which is being trialled on burns patients.
Decorin would allow the wound to be closed with normal tissue rather than scar tissue, bringing an end to disabling disfigurements caused by burns.
Hyaluronic acid contributes 8-20% of the ground substance that attracts more water and collagen decorin interaction is decreased that causes disorganisation of collagen bundles.
Control of proliferation, migration, and invasiveness of human extravillous trophoblast by decorin, a decidual product.
For an inhibition of binding assay (IBA), a petri dish was coated overnight with phosphate-buffered saline (PBS) containing 1% bovine serum albumin (BSA) and 5 [micro]g/mL decorin (chondroitin sulfate proteoglycan [CSPG]; Sigma, St.
Asporin is a member of the sub family of small leucine-rich proteoglycans that also includes decorin and biglycan.
2,3] Fibromodulin is a SLRP that along with other SLRPs such as decorin can interact with several different cell surface receptors, cytokines, ECM components, and growth factors such as TGF-[beta] ligands to modulate their [activity.
Decorin also participates in signal transduction [25].
The researchers have injected a synthetic version of a naturally occurring human protein called decorin, and prevented development of the damaging scar tissue which leads to hydrocephalus.
3) Biglycan and decorin belong to the family of small leucine-rich proteoglycans (SLRPs).
Washington, June 30 (ANI): Researchers from Thomas Jefferson University's Kimmel Cancer Center have discovered that decorin, a naturally occurring protein that circulates in the blood, acts as a potent inhibitor of tumor growth modulating the tumor microenvironment.