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decompensation |
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decompensation /de·com·pen·sa·tion/ (de″kom-pen-sa´shun) 1. inability of the heart to maintain adequate circulation, marked by dyspnea, venous engorgement, and edema. 2. in psychiatry, failure of defense mechanisms resulting in progressive personality disintegration.
decompensation [dē′kəmpənsā′shən] Etymology: L, de + compensare, to balance 1 the failure of a system, as cardiac decompensation in heart failure. 2 (in psychology) the failure of a defense mechanism. decompensation (dē·k n 1. a persistent (yet reversible, in some cases) pattern of dysfunction, in which homeostatic mechanisms are overwhelmed, either in part or completely.
2. postural pattern in which the musculoskeletal system indicates dysfunctional ad-justments as a result of a physical anomaly, such as shortened leg. decompensation failure of compensation. cardiac decompensation
inability of the heart to maintain adequate circulation; it is marked by dyspnea, venous engorgement, cyanosis and edema. decompensation Failure of an organ to fulfill its function adequately. Examples: corneal decompensation following years of extended contact lens wear; a failure of the eye movement system to overcome a heterophoria.
decompensation Medtalk An acute exacerbation or worsening of a clinical condition–eg schizophrenia, renal failure, liver failure, which had been held in check by compensatory mechanisms Psychiatry The exacerbation of a mental
condition–eg schizophrenia, that occurs when corrective mechanisms cannot maintain the individual at an optimal level of functioning; the deterioration of existing defenses, leading to an exacerbation of pathologic behavior. See Nervous
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It is indicated for the treatment of patients suffering from acute hepatic encephalopathy due to decompensating liver disease and drug overdose. The company has two lead product candidates, CPC-111 (currently in Phase II trials for acute complications of angioplasty, cardiac surgery, decompensating heart failure and sickle cell crisis) and CPC-211 (currently in Phase II clinical trials for ischemic stroke and closed head injury). The company has two lead product candidates, CPC-111 (currently in Phase II trials for patients with decompensating heart failure, and cardiac bypass) and CPC-211 (currently in a Phase II trial in ischemic stroke). |
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