Death Domain

Also found in: Acronyms.
A molecular domain present in many apoptosis pathway proteins and others for which there is no known role in apoptosis. Several death domain-containing proteins serve as adaptor molecules, mediating associations between proteins that contain DDs—homotypic DD interactions
References in periodicals archive ?
Silencing of fas-associated death domain protects mice from septic lung inflammation and apoptosis.
fkm = carboxy-valyl-alanyl-aspartyl-(o-methyl)-fluromethyl ketone, VX-166=pan caspase inhibitor, RNA = ribonucleic acid, BcI = B cell lymphoma, FAS = cell surface Fas receptor also known as CD95L, BIM= Bcl-2-interacting moderator of cell death, FADD = FAS associated death domain protein, PUMA = p53-upregulated modulator of apoptosis, HIV = human immunodeficiency virus.
The X-ray crystal structure of the Fas-FADD death domain complex revealed a particular arrangement of four FADD death domains bound to four Fas death domains.
You need a special arrangement of Fas receptors to trigger opening of the Fas death domain, and only then do you get activation.
Rockville, MD) and University of Michigan (Ann Arbor, MI) have patented Death Domain Containing Receptor-4 (DR4) proteins which are members of the tumor necrosis factor receptor family.
Caspase 8 is composed of two death domains and a cysteine protease domain.