titration (redirected from Dean and Webb titration)

titration /ti·tra·tion/ (ti-tra´shun) determination of a given component in solution by addition of a liquid reagent of known strength until the endpoint is reached when the component has been consumed by reaction with the reagent.

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ti·tra·tion (t-trshn)

n.

The process, operation, or method of determining the concentration of a substance in a solution to which the addition of a reagent having a known concentration is made in carefully measured amounts until a reaction of definite and known proportion is completed, as shown by a color change or by electrical measurement, and then calculating the unknown concentration.

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titration

[tītrā′shən]

a method of estimating the amount of solute in a solution. The solution is added in small, measured quantities to a known volume of a standard solution until a reaction occurs, as indicated by a change in color or pH or the liberation of a chemical product.

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titration (tītrā´shn),

n incremental increase in drug dosage to a level that provides the optimal therapeutic effect.

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titration

1. in chemistry, the determination of a given component in solution by addition of a liquid reagent of known strength until a given end point, e.g. change in color, is reached indicating that the component has been consumed by reaction with the reagent.

2. in serology, the serial dilution of serum, often in two- or 10-fold steps to determine the highest dilution that still contains detectable amounts of antibody. The reciprocal of that dilution is referred to as the antibody titer of that serum.

3. in microbiology, the serial dilution of a suspension of microorganisms; each dilution, usually in replicas of 4 or 5, is then inoculated onto a substrate such as agar plate (bacteria) or cell culture (viruses) such that the number of organisms present in one or more of the higher dilutions can be accurately counted and used to infer the number of organisms in the original undiluted suspension.

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Dean and Webb titration

a test for measuring antibody in which varying dilutions of antibody are mixed with a constant quantity of antigen; antibody activity is determined by the dilution in which flocculation occurs most rapidly, i.e. the end point.

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titration

Medtalk The serial dilution of a substance of interest. See Checkerboard titration.