Darier's disease

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keratosis

 [ker″ah-to´sis]
any horny growth, such as a wart or callosity.
actinic keratosis a sharply outlined wartlike or keratotic growth, which may develop into a cutaneous horn, and may become malignant; it usually occurs in the middle aged or elderly and is due to excessive exposure to the sun. Called also senile or solar keratosis. (See Atlas 3, Part F).
keratosis follicula´ris a slowly progressive autosomal dominant disorder of keratinization characterized by pinkish to tan or skin-colored papules on the seborrheic areas of the body that coalesce to form plaques, which may become crusted and secondarily infected; over time, the lesions may become darker and may fuse to form papillomatous and warty malodorous growths. Called also Darier's disease and Darier-White disease.
keratosis palma´ris et planta´ris palmoplantar keratoderma.
keratosis pharyn´gea horny projections from the tonsils and pharyngeal walls. Called also pharyngokeratosis.
keratosis pila´ris hyperkeratosis limited to the hair follicles.
keratosis puncta´ta a hereditary hyperkeratosis in which the lesions are localized in multiple points on the palms and soles.
seborrheic keratosis (keratosis seborrhe´ica) a benign, noninvasive tumor of epidermal origin, marked by numerous yellow or brown, sharply marginated, oval, raised lesions.
senile keratosis (solar keratosis) actinic keratosis.

Darier's disease

Darier's disease

Keratosis follicularis, a rare autosomal dominant skin disease caused by mutations on Chromosome 12. It features warty, foul-smelling plaques formed of coalesced greasy plaques of seborrhoeic dermatitis with severe itching and sometimes pain. The disease is chronic and may worsen with age. Treatment is with oral retinoids. Prenatal diagnosis by DNA analysis of cells obtained by chorionic villus sampling is possible.
Darier's disease; keratosis follicularis progressive autosomal-dominant disorder of keratinization characterized by dark, coalescent, papillomatous/warty epidermal growths
References in periodicals archive ?
Sonia Freeman, who suffers with the rare skin condition Darier's disease, with husband Leigh PICTURE: Andrew Davies [umlaut]
Dhitavat J, Macfarlane S, Dode L et al: Acrokeratosis verruciformis of Hopf is caused by mutation in ATP2A2: evidence that it is allelic to Darier's disease.
Sonia, 28, of Clive Street, Grangetown, Cardiff, was only diagnosed with Darier's Disease eight years ago although she's been affected since she was a child.
Differential diagnosis of pemphigus vulgaris Clinical diagnoses Mucosal Cutaneous Histologic diagnoses Aphthous stomatitis Bullous drug eruptions Hailey-Hailey disease Erythema multiforme Bullous pemphigoid Darier's disease Bullous lichen planus Drug-induced pemphigus Grover's disease Cicatricial pemphigoid Erythema multiforme Herpetic stomatitis Hailey-Hailey disease Linear immunoglobulin A dermatosis Paraneoplastic pemphigus Pemphigus foliaceus Transient acantholytic dermatosis (Grover's disease) Table 2.
Dermatological diseases in which Koebner's phenomenon occurs Contact dermatitis Molluscum contagiosum Darier's disease Pellagra Dermatographism Perforating disorders Eruptive xanthoma Pityriasis rubra pilaris Erythema multiforme Porokeratosis Henoch-Schonlein purpura Psoriasis * Kyrle's disease Reactive perforating collagenosis Lichen nitidus Rhus dermatitis * Lichen planus * Verrucae * Lichen sclerosus et atrophicus Vitiligo * Most frequently seen Table 2.
In dermatology, gene mapping has been used to map several inherited disorders in recent years, including different forms of epidermolysis bullas (blistering diseases), ichthyoses (scaling diseases), keratodermas, Darier's disease, Hailey-Hailey disease and PXE, among others.
Darier's sign is often present in these lesions, and bullae may develop.