desmoplastic small round-cell tumour

(redirected from DSRCT)
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desmoplastic small round-cell tumour

An aggressive, poorly-differentiated malignancy that often arises on serosal surfaces—peritoneum, tunica vaginalis, pleura—as well as in the CNS and lymph nodes of younger, more commonly male, patients.
 
Clinical findings
Abdominal distention, mass, and pain; back pain; gastrointestinal obstruction; anorexia; ascites; anaemia; cachexia.
References in periodicals archive ?
3-5,12) Although the function of the EWS-WT1 gene fusion and its role in tumorigenesis remains unclear, detection of the chimeric transcripts by reverse transcriptase/polymerase chain reaction provides a reliable means to accurately differentiate DSRCT from its numerous diagnostic mimics.
In summary, DSRCT may occasionally generate significant diagnostic dilemma because of unusual morphologic patterns and lack of expression of epithelial markers.
Additionally, both probe sets were hybridized to a tissue microarray constructed from normal tissue samples (colon, lymph node) and rhabdomyosarcomas (these served as normal/negative controls), Ewing/primitive neuroectodermal tumors (positive control for break-apart EWS-R1 cocktail), and DSRCTs (positive control for both probe sets).