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A gene on chromosome 1p36.1-p35 that encodes a member of the ephrin-B receptor subfamily of receptor tyrosine kinases, which “promiscuously” bind membrane-bound ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signalling into neighbouring cells. EPHB2 functions in axon guidance during development, guiding commissural axons and forming a major interhemispheric connection between the two temporal lobes of the cerebral cortex. EPHB2 is also involved in the guidance of contralateral inner ear efferent growth cones at the midline, and of retinal ganglion cell axons to the optic disk. It also regulates dendritic spines development and maturation, and it stimulates the formation of excitatory synapses.

Activation of EPHB2 by EFNB1 abolishes the ARHGEF15-mediated negative regulation on excitatory synapse formation. EPHB2 also controls other aspects of development, including angiogenesis, palate development, as well as inner ear development by regulating endolymph production. It may act as a tumour suppressor.

Molecular pathology
Defects in EPHB2 have been linked to prostate cancer.


Dead right there Medtalk A macabre adjective referring to a Pt who has been clinical kaputt long enough to minimize the likelihood of resuscitation
References in periodicals archive ?
DRT enhances Atmel Studio 7 by enabling superior quality C and C++ code generation for Atmel | SMART ARM-based microcontrollers(MCUs), resulting in reduced flash requirement for applications, faster code execution, and reduced power consumption.
The DRT will continue to play a critical role in ensuring the Tribhuvan Kathmandu International Airport remains operational.
It is certainly not negligible, but some other variants of DRT bring significantly higher savings.
For the Cooperative Vehicle-Highway testbed, the DRT provides data management and visualization services, making the data available for research and analysis.
On game, the DRT bullet is designed to penetrate 1-1/2" to 2" and then disintegrate along a trajectory of 10" creating a permanent wound cavity 6" to 8" in diameter.
Mr Salehi was one of more than 20 DHL Middle East DRT volunteers expected to be deployed to Pakistan during what is likely to be a three-week operation.
Millions of people are affected by the water and temporary shelter is the greatest need, particularly food, tents and tarpaulins," says Chris Weeks, Director, Humanitarian Affairs, Deutsche Post DHL who is currently on-the-ground with the DRT Middle East team in Islamabad.
DRT against the borrower Birendra Kanaudiya as he has started repaying the loan like a normal borrower.
One of the reasons for selecting the LJ DRT Toploader is that it offers the possibility to achieve faster loading speeds than its previous LJ RT machines.
The coupling rod of the DRT was attached to the ossicles with Crystalbond adhesive.
Neath PT will have the advantage of having already played one DRT game - walloping Bassaleg CS 76-10 - and with some terrific new recruits in scrum-half Tavis Knoyle from Ystalyfera and centre Ashley Beck from Dwr Y Felin CS, will be very hard to beat this season.
A piece of schools' rugby history was made at the Gnoll yesterday when Swansea College became the first side to do back-to-back DRT League and Welsh Schools Cup doubles, in beating Pencoed in the final of the Gullivers Sports Travel U18 Cup, writes Huw S Thomas.