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A gene on chromosome 1p36.1-p35 that encodes a member of the ephrin-B receptor subfamily of receptor tyrosine kinases, which “promiscuously” bind membrane-bound ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signalling into neighbouring cells. EPHB2 functions in axon guidance during development, guiding commissural axons and forming a major interhemispheric connection between the two temporal lobes of the cerebral cortex. EPHB2 is also involved in the guidance of contralateral inner ear efferent growth cones at the midline, and of retinal ganglion cell axons to the optic disk. It also regulates dendritic spines development and maturation, and it stimulates the formation of excitatory synapses.

Activation of EPHB2 by EFNB1 abolishes the ARHGEF15-mediated negative regulation on excitatory synapse formation. EPHB2 also controls other aspects of development, including angiogenesis, palate development, as well as inner ear development by regulating endolymph production. It may act as a tumour suppressor.

Molecular pathology
Defects in EPHB2 have been linked to prostate cancer.


Dead right there Medtalk A macabre adjective referring to a Pt who has been clinical kaputt long enough to minimize the likelihood of resuscitation
References in periodicals archive ?
Linear mixed-effects model was used to determine the effect of degree of femur rotation on repeated measurements of DRT or FVA.
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The conditions of the PT and the DRT in these experiments were the same as in the previous study [10].
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DRT has built a different mousetrap--not a better mousetrap necessarily, but one that certainly is effective on game.
Beal's secret is he has been able to control the frangibility of the DRT bullet in organic targets containing fluid-making it exceedingly lethal, as I was to find out on the hunt.
The DRT will provide its services pro bono in close cooperation with the United Nations Office for the Coordination of Humanitarian Affairs (UN OCHA).
Twenty-five volunteers from DHL's DRT Middle East and Asia Pacific office are expected to be deployed on the ground in Pakistan for up to three weeks to help unload and palletise goods.
The DRT was set up in 2004 to assist in the recovery operations following natural disasters.