DRD4


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DRD4

A gene on chromosome 11p15.5 that encodes a G protein-coupled dopamine receptor responsible for neuronal signalling in the mesolimbic system of the brain, an area of the brain that regulates emotion and complex behaviour. Soft data suggest that DRD4 may play a role in novelty-seeking behaviour.
References in periodicals archive ?
org/content/274/1619/1685) 2007 study conducted by researchers from the Max Planck Institute for Ornithology using a small group of hand-raised great tits found a correlation between a certain variant of DRD4 and stronger exploratory behavior.
The fast pace of today's culture, video games with instant rewards, and too little active play and exercise add fuel to the DRD4 fire.
The DRD4 gene encodes a dopamine receptor, a lock-like molecule that triggers nerve activity when dopamine fits into it like a key.
DRD4 and DAT, the most well studied genes for ADHD, showed the strongest effects on methylphenidate dose-response in study participants, according to the researchers.
Many bearers of this variant of the DRD4 gene would have had the requisite personalities to head up migrating groups, Ding's group asserts in the Jan.
According to the study, the three genes that have been identified are - DAT1, DRD2 and DRD4 - which have been linked to behaviors such as attention regulation, motivation, violence, cognitive skills and intelligence.
Specifically, their analysis of the polymorphisms in DRD4 indicated that those with any-3R genotype experienced a significantly higher risk of early onset of first sexual intercourse than those with other (or any-4R) genotype in a large sample consisting of Asian, White, and Hispanic ethnicities.
The analysis of 51 genes in DSM-IV combined type attention deficit hyperactivity disorder: association signals in DRD4, DAT1 and 16 other genes.
Variants of two genes for brain receptors for dopamine, known as DRD2 and DRD4, didn't appear to affect youngsters' responses to methylphenidate in Winsberg and Comings' study.
Those with a certain variant of the DRD4 gene were more likely to report having had one-night stands and adulterous affairs.
The biggest culprit seems to be the dopamine receptor D4 polymorphism, or DRD4 gene.