DRD4


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DRD4

A gene on chromosome 11p15.5 that encodes a G protein-coupled dopamine receptor responsible for neuronal signalling in the mesolimbic system of the brain, an area of the brain that regulates emotion and complex behaviour. Soft data suggest that DRD4 may play a role in novelty-seeking behaviour.
References in periodicals archive ?
The association between political attitude and DRD4 was highly significant for females," and less so for men, said the study, led by Richard Ebstein of the National University of Singapore.
Family-based and case-control association studies of DRD4 and DAT1 polymorphisms in Chinese attention deficit hyperactivity disorder patients suggest long repeats contribute to genetic risk for the disorder.
The DRD4 7R allele blunts dopamine signaling, which enhances individuals' reactivity to their environment.
InDel typing of the gene DRD4, SLC6A3 and SLC6A4 were conducted in multiplex PCR.
Researchers have been examining DRD4 in a songbird called the great tit to see if any variants of the gene correlate with more adventurous birds.
that specific genotypes of DRD4 and DRD5 are associated with increased risk of ADHD [36].
Researcher Justin Garcia, from the University of New York, said: "What we found was that individuals with a certain variant of the DRD4 gene were more likely to have a history of uncommitted sex, including one-night stands.
Olumsuz ebeveyn tutumlari, arkadaslari tarafindan kabul edilmeme, dusuk dogum agirligi, ailede DEHB oykusu, DAT1 ve DRD4 genlerinde polimorfizm ve COMT (katekol-o-metil-transferaz) geninin valin-valin genotipinin bulunmasi olumsuz gidis etkenleri olarak bildirilmistir (20).
In particular, variations in DRD4, the dopamine D4 receptor gene, may help explain why some people have strong religious impulses while others do not.
Researchers at Harvard and the University of California were poking around chromosome 11 on the human DNA chain and looked more closely at sequence DRD4.
The folks, who had been subjected to the experiment, have clearly produced a strong statistical relationship between the presence of DRD4 in their blood cells - or any other cell - and liberalism; the scatter graph speaks for itself, according to the learned men who broke the news to a global audience, most of which, is becoming increasingly liberal, wherever you look at; the correlation is breathtakingly real.
The difference in the amplitude of ERN (including individual differences) that is reflected in the magnitude of phasic dopamine response in the process of error monitoring and processing (51,53), may be related to genetic variations in dopamine receptors, especially DRD2 and DRD4, as well as other genes coding for enzymes and transporters of dopamine like cathehol-O-methyltransferase (COMT) and dopamine transporter, DAT (36,51,105,109) (Fig 2).