DPP4

(redirected from DPPIV)
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DPP4

A gene on chromosome 2q24.3 that encodes dipeptidyl-peptidase 4, a ubiquitous, membrane-bound enzyme with roles in nutrition, metabolism, the endocrine system, immune regulation (for instance, it is essential for T-cell receptor (TCR)-mediated T-cell activation), bone marrow mobilisation, apoptosis, cell adhesion and tumourigenesis.
References in periodicals archive ?
The algorithm does not, at this stage, suggest a role for the newer agents such as the incretins and DPPIV inhibitors.
The search for a treatment for T2DM using GLP-1 has centered on finding a GLP-1 mimetic resistant to degradation by DPPIV or designing a drug that could inhibit DPPIV, thereby prolonging the incretin effect.
It is resistant to degradation by DPPIV, and requires subcutaneous injection twice daily.