DDX20

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DDX20

A gene on chromosome 1p21.1-p13.2 that encodes a protein which has a conserved Asp-Glu-Ala-Asp (DEAD) motif and is an ATP-dependent RNA helicase belonging to the SMN complex, which plays a key role in spliceosomal snRNP assembly in the cytoplasm. The complex is required for pre-mRNA splicing in the nucleus and may play a role in snoRNP metabolism.
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DP103 acts as a master regulator, which expresses two sets of unfavourable proteins - one leads to metastasis and the other causes patients to be unresponsive to chemotherapy.
This DP103 gene that we found explains the link and will facilitate doctors in selecting suitable treatments for different cases of breast cancer," said Dr Tergaonkar.
In addition, the study revealed that reducing the levels of DP103 could contain the cancer, shrink the tumour and make patients more amenable to chemotherapy.
He is also the Principal Inventor to a patent application on this discovery and is currently looking into ways to regulate DP103 levels in a variety of cancer types at CSI Singapore.
Unique features include an alder body with Road Worn aged finish and hardware treatment, bound fretboard with pearloid dot markers, Stratocaster headstock shape with 1950s-style "spaghetti" logo under the finish, DiMarzio([R]) humbucking DP103 PAF 36th Anniversary neck pickup and DP100 Super Distortion bridge pickup, triple knurled "chrome-dome" knob configuration (volume-volume-tone), three-position toggle switch, black chrome Adjusto-Matic([TM]) bridge and Gotoh([R]) sealed tuners.