DOK3

(redirected from DOKL)

DOK3

A gene on chromosome 5q35.3 that encodes an enzymatically inert adaptor/scaffolding protein, which provides the docking platform for assembling multimolecular signalling complexes. DOK3 is a negative regulator of JNK signalling in B-cells via INPP5D/SHIP1; it may modulate ABL1 function. It is expressed in the spleen.