DOK3

DOK3

A gene on chromosome 5q35.3 that encodes an enzymatically inert adaptor/scaffolding protein, which provides the docking platform for assembling multimolecular signalling complexes. DOK3 is a negative regulator of JNK signalling in B-cells via INPP5D/SHIP1; it may modulate ABL1 function. It is expressed in the spleen.
References in periodicals archive ?
Singapore, Sept 1, 2014 - (ACN Newswire) - Scientists from A*STAR's Bioprocessing Technology Institute (BTI) have uncovered the crucial role of two signalling molecules, DOK3 and SHP1, in the development and production of plasma cells.
For the first time, the molecule DOK3 was found to play an important role in formation of plasma cells.
Proceedings of the National Academy of Sciences of the United States of America (PNAS) Journal, under the title, "Adaptor protein DOK3 promotes plasma cell differentiation by regulating the expression of programme cell death 1 ligands" by Xijun Ou,1, Shengli Xu,1,2, Yan-Feng Li,1, Kong Peng Lam,1,2,3,4