DOG1

DOG1

A gene—Discovered On Gastrointestinal stromal tumours protein 1—that was first identified in the so-called K9 clone, the protein product of which is a highly specific marker for gastrointestinal stromal tumours.
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For immunohistochemistry the following antibodies were used: CD34 (1:50; Novocastra, Newcastle, United Kingdom), CD117 and S100 (rabbit polyclonal), and smooth muscle actin (SMA), calponin, and anaplastic lymphoma kinase-1 (ALK-1) (mouse monoclonal) 1:400, 1:800, 1:100, 1:50, and undiluted, respectively; DAKO, Glostrup, Denmark); DOG1 (rabbit polyclonal, 1:100; Spring Bioscience, Pleasanton, California); and PDGFRA (rabbit polyclonal, 1:400; sc-338, Santa Cruz Biotechnology, Inc, Santa Cruz, California).
Tumor mesenchymal cells were strongly immunopositive for CD34 (Figure 1, C) and negative for CD117 (which highlighted the infiltrating mast cells) (Figure 1, D); additionally, PDGFRA immunoreaction did not show any significant staining, and stainings with DOG1, S100, calponin, SMA, and ALK-1 were all negative (not shown).
Immunohistochemistry showed strong nuclear expression for beta-catenin but was negative for C-KIT, CD34 and DOG1 consistent with a diagnosis of desmoid tumour (3,4,5).
DOG1 antibody is a highly sensitive and specific marker for gastrointestinal stromal tumors in cytology cell blocks.
Simply text DOG1 followed by a space and the four digit code of your favourite baby followed by your name, address and postcode to 84080.
Jin identified four genes (MSN2, DOG1, HAL1, and INO1) that improve tolerance to ethanol and iso-butanol when they are overexpressed.
By immunohistochemistry, most GISTs are positive for KIT (CD117) and DOG1 (discovered on GIST), and often also for CD34.
15,16) In these cases, immunostaining for DOG1 (17,18) and PKC019 can be useful to confirm the diagnosis.
Simply text DOG1 followed by a space and the four digit code of your favourite dog followed by your name, address and postcode to 84080.
Although ANO1 (also known as TMEM161A and FLJ10261) is the approved gene symbol, DOG1 is the most commonly used name in the diagnostic literature.
14) In a large study comparing DOG1 expression with CD117, the authors (14) found that overall, 87% of GIST were positive for DOG1, whereas only 74% of them expressed CD117.